2023
Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation
van der Meer D, Cheng W, Rokicki J, Fernandez-Cabello S, Shadrin A, Smeland O, Ehrhart F, Gülöksüz S, Pries L, Lin B, Rutten B, van Os J, O’Donovan M, Richards A, Steen N, Djurovic S, Westlye L, Andreassen O, Kaufmann T, Aguilar E, Akdede B, Alptekin K, Altınyazar V, Amoretti S, Andric-Petrovic S, Arango C, Arrojo M, Atbaşoğlu C, Bernardo M, Binbay T, Bobes J, Cankurtaran E, Carracedo A, Cihan B, Delespaul P, García-Portilla M, González-Peñas J, Guloksuz S, Gümüş-Akay G, Jiménez-López E, Ulusoy Kaymak S, Kenis G, Lin B, López G, Luykx J, Maric N, Mezquida G, Mihaljevic M, Mirjanic T, Parellada M, Pries K, Rivero O, Rutten B, Saiz P, Can Saka M, Sanjuan J, Luis Santos J, Soygür H, Üçok A, Ulaş H, van Os J, Yalınçetin B, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, van Os J, Veling W. Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation. Schizophrenia Bulletin 2023, 50: 327-338. PMID: 37824720, PMCID: PMC10919784, DOI: 10.1093/schbul/sbad140.Peer-Reviewed Original ResearchAge-matched healthy controlsBrain maturational processesIndependent clinical cohortsOnset of symptomsPolygenic riskCortical tissue samplesGenetic risk factorsDevelopment of schizophreniaHeritable brain disorderSymptom onsetHealthy controlsRisk factorsClinical cohortEarly neurodevelopmentPolygenic risk scoresRisk scoreImmune systemSchizophrenia diagnosisBrain disordersSchizophreniaNeuronal communicationStrong associationEarly adulthoodTissue samplesMaturational processes
2020
Predictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScores