2020
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain
Schmidt-Kastner R, Guloksuz S, Kietzmann T, van Os J, Rutten B. Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain. Frontiers In Psychiatry 2020, 11: 393. PMID: 32477182, PMCID: PMC7235330, DOI: 10.3389/fpsyt.2020.00393.Peer-Reviewed Original ResearchObstetric complicationsIschemia-hypoxiaHypoxia-inducible factorNervous systemSynaptic functionMonogenic disordersFocal brain ischemiaGenome-wide association studiesChi-square testSCZ genesEarly brain developmentBrain ischemiaMental disordersMutation-intolerant genesBrain developmentSCZ genome-wide association studySynaptic genesDisordersBh geneSchizophreniaBrainGene setsResponse genesSchizophrenia genesSubset
2019
Involvement of hemoglobins in the pathophysiology of Alzheimer's disease
Altinoz M, Guloksuz S, Schmidt-Kastner R, Kenis G, Ince B, Rutten B. Involvement of hemoglobins in the pathophysiology of Alzheimer's disease. Experimental Gerontology 2019, 126: 110680. PMID: 31382012, DOI: 10.1016/j.exger.2019.110680.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurodegenerative disordersPathogenesis of ADCourse of ADNitric oxideIncreased Hb levelsTangle-bearing neuronsInner mitochondrial membraneBlood-brain barrierAD brain samplesLevels of HbCentral nervous systemHeme-containing proteinsRole of HbFunction of intracellularMultiple beneficial effectsHb transcriptionHb levelsAD brainImmunohistochemical studyMitochondrial membranePossible candidate moleculesBiological processesCellular respirationNervous system