Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
Sahbaz C, Zibandey N, Kurtulmus A, Duran Y, Gokalp M, Kırpınar I, Sahin F, Guloksuz S, Akkoc T. Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia. Psychopharmacology 2020, 237: 1861-1871. PMID: 32221694, DOI: 10.1007/s00213-020-05504-0.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsRegulatory T cellsHealthy controlsT cellsIL-17AIL-6Smoking status-matched healthy controlsCulture supernatant levelsT cell percentageTh1/Th2Levels of Foxp3Blood mononuclear cellsBody mass indexImmune imbalanceTreg percentageMass indexProinflammatory cytokinesMethodsForty patientsMononuclear cellsPlasma levelsProinflammatory responseSupernatant levelsCell percentageResultsIn comparisonArray kit