2020
Predictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScoresMinor Physical Anomalies in Bipolar Disorder
İnce B, Altinoz M, Ayran A, Cansız A, Altinbaş K, Guloksuz S, Kurt E. Minor Physical Anomalies in Bipolar Disorder. Comprehensive Psychiatry 2020, 103: 152206. PMID: 33099105, DOI: 10.1016/j.comppsych.2020.152206.Peer-Reviewed Original ResearchConceptsBipolar disorderMinor physical anomaliesBD patientsHealthy subjectsHigh arched palatePhysical anomaliesAuricular anomaliesPsychiatric disordersCleft lipPathogenesis pathwaysPatientsMinor anomaliesDeletion syndromeDisordersSecond pharyngeal archesDorsal endPalateSchizophreniaRegression modelsAuriclePharyngeal archesFirst pharyngeal archArchNew endophenotypesSubjectsThiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Erzin G, Özkaya G, Topçuoğlu C, Yüksel R, Erel Ö, Yurt E, Göka E, Gülöksüz S. Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression. Clinical Psychopharmacology And Neuroscience 2020, 18: 395-401. PMID: 32702218, PMCID: PMC7383011, DOI: 10.9758/cpn.2020.18.3.395.Peer-Reviewed Original ResearchDisulfide/total thiol ratiosTotal thiol ratiosThiol-disulfide homeostasisBipolar depressionHealthy controlsUnipolar depressionNative thiol ratioBipolar disorderDisulfide levelsThiol ratioDepressive disorderNative thiolAnkara Numune TrainingThiol/disulfide homeostasisDisulfide/native thiol ratioOxidative stress markersUnipolar depressive disorderDSM-5 criteriaLevels of disulfideUD groupOutpatient clinicClinical entityDepressive episodeResearch HospitalTherapeutic differencesDo Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPainMeta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder
Atagun M, Drukker M, Hall M, Altun I, Tatli S, Guloksuz S, van Os J, van Amelsvoort T. Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder. Psychiatry Research Neuroimaging 2020, 300: 111078. PMID: 32361172, DOI: 10.1016/j.pscychresns.2020.111078.Peer-Reviewed Original ResearchConceptsP50 sensory gatingFirst-degree relativesBipolar disorderSensory gatingP50 sensory gating deficitsDual-click paradigmFirst-episode psychosisSensory gating functionSensory gating deficitsS1-S2 differenceEffect of diagnosisAuditory P50 sensory gatingSensory gating ratiosGating deficitsInclusion criteriaTreatment statusLongitudinal courseIllness statePoor real-world functioningLiterature searchSchizophreniaDisordersRedundant sensory inputsTrend levelNeurophysiological measures
2019
Affective Temperament and Seasonality in Bipolar Disorder.
Altınbaş K, İnce B, Gülöksüz S. Affective Temperament and Seasonality in Bipolar Disorder. Psychiatria Danubina 2019, 31: 106-110. PMID: 30948697, DOI: 10.24869/psyd.2019.106.Peer-Reviewed Original ResearchConceptsBipolar disorderIllness courseSeasonal Pattern Assessment QuestionnaireAffective temperamentsAnxious temperament scoresAssessment QuestionnaireEuthymic patientsTemperament scoresAffective temperament scoresTotal scoreMood regulationVersion scalePatientsScoresFurther investigationDisordersCourse
2018
Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients.
Altınbaş K, Yeşilbaş D, İnce B, Cansız A, Sılan F, Özdemir Ö, Gülöksüz S. Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients. Turkish Journal Of Psychiatry 2018, 29: 73-78. PMID: 30215834, DOI: 10.5080/u20582.Peer-Reviewed Original ResearchConceptsMean ageLithium treatmentTreatment responseGSK-3βBipolar disorder type IBipolar disorder patientsLack of evidenceClinical predictorsHospital recordsTreatment adherenceTreatment optionsDisease onsetFirst episodeReal-time PCRIndividualized treatmentPharmacogenomic findingsBlood samplesDisorder patientsSide effectsAG genotypeClinical practiceScale scoreBipolar disorderPatientsSample cohort
2014
Electrocardiography changes in bipolar patients during long-term lithium monotherapy
Altinbas K, Guloksuz S, Caglar I, Caglar F, Kurt E, Oral E. Electrocardiography changes in bipolar patients during long-term lithium monotherapy. General Hospital Psychiatry 2014, 36: 694-697. PMID: 25091141, DOI: 10.1016/j.genhosppsych.2014.07.001.Peer-Reviewed Original ResearchConceptsTherapeutic serum levelsHealthy controlsSerum levelsLithium monotherapyLithium levelsEuthymic BD type I patientsBipolar disorderLong-term lithium useBD type I patientsCardiovascular side effectsChronic lithium treatmentSerum lithium levelsVentricular electrical instabilityType I patientsQT dispersion ratioUse of lithiumElectrocardiography changesI patientsBD patientsTherapeutic rangeLithium treatmentQRS intervalQT dispersionLithium useElectrocardiogram parameters
2013
Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes
İnce B, Guloksuz S, Altınbaş K, Oral E, Alpkan L, Altinoz M. Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes. Journal Of Affective Disorders 2013, 151: 405-408. PMID: 23856286, DOI: 10.1016/j.jad.2013.06.042.Peer-Reviewed Original ResearchConceptsBipolar disorderEpisode densityProtective roleDisease severityLikely protective roleBrain blood flowElectro-convulsive therapyPositive family historyTotal body weightEuthymic BD patientsHigh-performance liquid chromatographyMyocardial anginaLarge comparative studiesIntermittent hypoxiaHemoglobin levelsCardiac outputDisease characteristicsBD patientsHypoxia hypothesisPostpartum episodesHbF increaseFamily historySevere bipolar disorderBlood flowDrug regimes
2012
Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms
Cetin T, Guloksuz S, Cetin E, Gazioglu S, Deniz G, Oral E, van Os J. Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms. BMC Psychiatry 2012, 12: 158. PMID: 23013558, PMCID: PMC3532147, DOI: 10.1186/1471-244x-12-158.Peer-Reviewed Original ResearchEvidence for an association between tumor necrosis factor-alpha levels and lithium response
Guloksuz S, Altinbas K, Cetin E, Kenis G, Gazioglu S, Deniz G, Oral E, van Os J. Evidence for an association between tumor necrosis factor-alpha levels and lithium response. Journal Of Affective Disorders 2012, 143: 148-152. PMID: 22749155, DOI: 10.1016/j.jad.2012.04.044.Peer-Reviewed Original ResearchConceptsTNF-α levelsBipolar patientsLithium responsePartial responseTumor necrosis factor-alpha levelsBipolar disorderTreatment-resistant bipolar patientsNecrosis factor-alpha levelsRole of inflammationPotential pathophysiological mechanismsAdditional inflammatory markersAssessment of responseGood responseEnzyme-linked immunosorbentEuthymic bipolar patientsImmune imbalanceImmune alterationsInflammatory markersImmune changesPathophysiological mechanismsPotential confoundersLithium therapyNatural coursePoor responseTreatment response
2011
P01-239 - The effects of childhood trauma on psychotic symptoms in bipolar disorder
Ozkose M, Guclu O, Guloksuz S, Karaca O, Yildirim B, Ince B, Erkmen H. P01-239 - The effects of childhood trauma on psychotic symptoms in bipolar disorder. European Psychiatry 2011, 26: 240. DOI: 10.1016/s0924-9338(11)71950-2.Peer-Reviewed Original ResearchYoung Mania Rating ScaleMontgomery-Asperg Depression Rating ScalePsychotic episodeBipolar patientsBipolar disorderChildhood Trauma QuestionnaireChildhood traumaPsychotic symptomsRating ScaleDuration of illnessSexual abuse scoresDepression Rating ScaleMania Rating ScaleStandard treatment planTerms of ageAbuse scoresDSM-IV-TRBakirkoy ResearchInpatient unitPatientsTraining hospitalsPhysical abuse scoresPositive symptomsTherapeutic interventionsTreatment plan
2010
Cytokine levels in euthymic bipolar patients
Guloksuz S, Cetin E, Cetin T, Deniz G, Oral E, Nutt D. Cytokine levels in euthymic bipolar patients. Journal Of Affective Disorders 2010, 126: 458-462. PMID: 20537397, DOI: 10.1016/j.jad.2010.04.027.Peer-Reviewed Original ResearchConceptsEuthymic bipolar patientsBipolar patientsCytokine levelsHealthy controlsBipolar disorderDepressive episodeLithium monotherapyIL-10 levelsIL-4 levelsSerum cytokine levelsPro-inflammatory stateEffects of medicationNeuro-immune modulationTerms of agePatients 16Cytokine profileCytokine productionPresent studyIL-2IL-4IL-5Healthy volunteersPsychiatric disordersPatientsFlow cytometryPW01-264 - How would European trainees treat bipolar disorder for their patients and themselves, and what influences decision-making?
Jauhar S, Lydall G, Riese F, Marques J, Bendix M, Andlauer O, Gerber S, De Vriendt N, Dumitrescu I, Nawka A, Guloksuz S, Mendonca L, Nwachukw I, Psaras R, Roventa C, Giacco D, Mufic A, Dobrzynska E, Nazaraliev A, Van Zanten J, Group E. PW01-264 - How would European trainees treat bipolar disorder for their patients and themselves, and what influences decision-making? European Psychiatry 2010, 25: 1596-1597. DOI: 10.1016/s0924-9338(10)71577-7.Peer-Reviewed Original ResearchThe treatment of bipolar disorder during pregnancy and the postpartum period.
Gülöksüz S, Akdeniz F, Ince B, Oral E. The treatment of bipolar disorder during pregnancy and the postpartum period. Turkish Journal Of Psychiatry 2010, 21: 155-66. PMID: 20514566, DOI: 10.5080/u6131.Peer-Reviewed Original ResearchConceptsPostpartum periodBipolar disorderPsychotropic medicationsBD patientsOnset of BDRisk of relapseRisk-benefit decisionsNeonatal toxicityPregnant patientsAdverse eventsObstetrical outcomesFetal exposureSafety profileBreast milkPharmacological treatmentPrevent recurrenceTreatment optionsMedication effectsPsychotropic agentsReproductive yearsNeurobehavioral developmentRecurrence increasesPregnancyPatientsMedications