2019
Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling
Asch R, Schurdak J, McNamara R. Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling. Nutritional Neuroscience 2019, 24: 735-746. PMID: 31599208, PMCID: PMC7145725, DOI: 10.1080/1028415x.2019.1674507.Peer-Reviewed Original ResearchConceptsPro-inflammatory signalingFatty acid deficiencyLicking/groomingAcid deficiencyCON damsDietary omega-3 fatty acid deficiencyOmega-3 fatty acid deficiencyLower RBCMaternal nurturing behaviorAlpha-linolenic acidNurturing behaviorInflammatory measuresDHA levelsPassive nursingBlinded ratersPotential associationControl dietAcid levelsRatsNursingFatty acid compositionPupsDeficiencyDietSignaling
2017
Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study
McNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.Peer-Reviewed Original ResearchConceptsDEF ratsFO ratsAMPH challengeAmphetamine treatmentDocosahexaenoic acidBOLD activationDHA levelsBilateral caudate putamenBrain DHA levelsErythrocyte DHA levelsNeuroplastic brain changesPharmacological magnetic resonanceBlood oxygen level-dependent (BOLD) responseAlpha-linolenic acidAttention deficit hyperactivity disorderLevel-dependent responsesGreater locomotor activityDeficit hyperactivity disorderDEF animalsBrain activation patternsPhMRI studiesAMPH injectionFatty acidsAMPH exposureBasal forebrainDeficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiffusion Tensor ImagingDocosahexaenoic AcidsMaleNeurogenesisProsencephalonRatsRats, Long-EvansWhite MatterConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale ratsGlutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study
McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.Peer-Reviewed Original ResearchConceptsDEF ratsGlutamate homeostasisPrefrontal cortexFO ratsDHA levelsAdult rat prefrontal cortexVivo 1H MRS studyMarkers of excitotoxicityFatty acid-deficient dietAstrocyte glutamate transportersH-MRS scansAdult rat brainRat prefrontal cortexAdult prefrontal cortexGlutamine/glutamate ratioDietary-induced alterationsMajor psychiatric disordersBrain DHAGlutamate levelsDiet groupGLAST expressionGlutamine synthetase expressionMRS scansAdolescent ratsRat brainEffects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study
Lindquist D, Asch R, Schurdak J, McNamara R. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study. Journal Of Psychiatric Research 2017, 95: 143-146. PMID: 28846858, PMCID: PMC5653412, DOI: 10.1016/j.jpsychires.2017.08.014.Peer-Reviewed Original ResearchConceptsMembrane phospholipid metabolismBrain DHA levelsDietary-induced alterationsDocosahexaenoic acidPhospholipid metabolismRat brainDHA levelsBrain docosahexaenoic acidMagnetic resonance spectroscopy studyAdult rat brainPeri-adolescent periodMitochondrial bioenergeticsDifferent psychiatric disordersAlpha-linolenic acidP MRS dataP-MRSDef dietFatty acidsSignificant group differencesMale ratsPhosphocreatine levelsAdult ratsPsychiatric disordersMRS studiesFO diet