Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale ratsEffects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study
Lindquist D, Asch R, Schurdak J, McNamara R. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study. Journal Of Psychiatric Research 2017, 95: 143-146. PMID: 28846858, PMCID: PMC5653412, DOI: 10.1016/j.jpsychires.2017.08.014.Peer-Reviewed Original ResearchConceptsMembrane phospholipid metabolismBrain DHA levelsDietary-induced alterationsDocosahexaenoic acidPhospholipid metabolismRat brainDHA levelsBrain docosahexaenoic acidMagnetic resonance spectroscopy studyAdult rat brainPeri-adolescent periodMitochondrial bioenergeticsDifferent psychiatric disordersAlpha-linolenic acidP MRS dataP-MRSDef dietFatty acidsSignificant group differencesMale ratsPhosphocreatine levelsAdult ratsPsychiatric disordersMRS studiesFO diet