Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study
McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.Peer-Reviewed Original ResearchConceptsDEF ratsGlutamate homeostasisPrefrontal cortexFO ratsDHA levelsAdult rat prefrontal cortexVivo 1H MRS studyMarkers of excitotoxicityFatty acid-deficient dietAstrocyte glutamate transportersH-MRS scansAdult rat brainRat prefrontal cortexAdult prefrontal cortexGlutamine/glutamate ratioDietary-induced alterationsMajor psychiatric disordersBrain DHAGlutamate levelsDiet groupGLAST expressionGlutamine synthetase expressionMRS scansAdolescent ratsRat brain