Functional diversity of the glutathione peroxidase gene family among human populations: implications for genetic predisposition to disease and drug response
Polimanti R, Fuciarelli M, Destro-Bisol G, Battaggia C. Functional diversity of the glutathione peroxidase gene family among human populations: implications for genetic predisposition to disease and drug response. Pharmacogenomics 2013, 14: 1037-1045. PMID: 23837478, DOI: 10.2217/pgs.13.99.Peer-Reviewed Original ResearchConceptsGlutathione peroxidase gene familyPeroxidase gene familyHuman genetic variationFunctional prediction analysisHigh functional impactHuman populationGenomes Project dataGene familyFunctional diversityRedox regulationGenetic variationDrug responseFunctional differencesFunctional impactAdaptation signalsCommon variantsDiverse responsesGlutathione peroxidaseRare variantsGPX3GPX1Prediction analysisVariantsDiverse susceptibilityDiversityMetal-score as a potential non-invasive diagnostic test for Alzheimer's disease.
Squitti R, Pasqualetti P, Polimanti R, Salustri C, Moffa F, Cassetta E, Lupoi D, Ventriglia M, Cortesi M, Siotto M, Vernieri F, Rossini PM. Metal-score as a potential non-invasive diagnostic test for Alzheimer's disease. Current Alzheimer Research 2013, 10: 191-8. PMID: 23036026, DOI: 10.2174/1567205011310020009.Peer-Reviewed Original ResearchAntioxidant Status and APOE Genotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia
Zito G, Polimanti R, Panetta V, Ventriglia M, Salustri C, Siotto MC, Moffa F, Altamura C, Vernieri F, Lupoi D, Cassetta E, Rossini PM, Squitti R. Antioxidant Status and APOE Genotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia. Rejuvenation Research 2013, 16: 51-56. PMID: 23216585, PMCID: PMC3582293, DOI: 10.1089/rej.2012.1383.Peer-Reviewed Original ResearchConceptsAntioxidant statusΕ4 alleleVascular dementiaHealthy controlsSerum total antioxidant statusOxidative stressHigher WMH scoresTotal antioxidant statusWhite matter hyperintensitiesAPOE ε4 alleleElderly healthy controlsWMH scoresVaD patientsAtrophy assessmentLipid dyshomeostasisNeurodegenerative processesMatter hyperintensitiesPathogenetic pathwaysApolipoprotein EAlzheimer typeSystem homeostasisAlzheimer's diseaseTAS concentrationDisease riskLipid metabolism