2016
Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children
Karaca S, Civelek E, Karaca M, Sahiner UM, Ozgul RK, Kocabas CN, Polimanti R, Sekerel BE. Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children. Scientific Reports 2016, 6: 33152. PMID: 27624002, PMCID: PMC5021980, DOI: 10.1038/srep33152.Peer-Reviewed Original ResearchConceptsHypertonic saline challenge testTurkish childrenAllergic airway inflammationPhenome-wide association studySkin prick testRole of immunogeneticsCross-sectional studyDifferent immune functionsAllergic bronchitisCD14 rs2569190Airway inflammationAtopic marchPrick testAsthma diagnosisLung functionBlood testsIL4 rs2243250Immune functionChallenge testAssociation studiesADAM33ComorbiditiesChildrenAssociationAsthmaHaplotype analysis of non-HLA immunogenetic loci in Turkish and worldwide populations
Karaca S, Karaca M, Civelek E, Ozgul RK, Sekerel BE, Polimanti R. Haplotype analysis of non-HLA immunogenetic loci in Turkish and worldwide populations. Gene 2016, 587: 132-136. PMID: 27129937, DOI: 10.1016/j.gene.2016.04.050.Peer-Reviewed Original Research
2015
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population
Karaca S, Erge S, Cesuroglu T, Polimanti R. Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. Nutrition 2015, 32: 693-701. PMID: 26856649, DOI: 10.1016/j.nut.2015.12.027.Peer-Reviewed Original ResearchConceptsDietary habitsCausative relationshipGenetic predispositionTurkish populationDifferent cardiometabolic diseasesGenetic factorsCardiometabolic diseasesRisk factorsNutritional habitsDisease riskDifferent biological mechanismsMetabolic traitsSignificant correlationCausative networkGenetic variantsBiological mechanismsGenetic associationCMTPresent studyPredispositionLifestyleAnthropometric traitsHabitsPopulationFactorsInternational warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events
Karaca S, Bozkurt NC, Cesuroglu T, Karaca M, Bozkurt M, Eskioglu E, Polimanti R. International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events. Pharmacogenomics 2015, 16: 1109-1118. PMID: 26216670, DOI: 10.2217/pgs.15.58.Peer-Reviewed Original ResearchConceptsLife-threatening hemorrhagic eventsHemorrhagic eventsPharmacogenetic algorithmWarfarin doseTurkish patientsTherapeutic warfarin doseHistory of bleedingLarge multiethnic cohortTherapeutic warfarin dosesWarfarin pharmacogenetic algorithmsThromboembolic eventsWarfarin dosesPreventive effectTherapeutic doseMultiethnic cohortPatientsTurkish populationAbstractTextDoseWarfarinCohortBleedingHemorrhagicDosesGenetic diversity of disease-associated loci in Turkish population
Karaca S, Cesuroglu T, Karaca M, Erge S, Polimanti R. Genetic diversity of disease-associated loci in Turkish population. Journal Of Human Genetics 2015, 60: 193-198. PMID: 25716910, DOI: 10.1038/jhg.2015.8.Peer-Reviewed Original ResearchConceptsHealth-related traitsGenetic diversityNon-European ancestryHuman genetic variationDisease-associated lociGenetic structureComplex traitsGenetic variationTraitsEuropean individualsGenesEast populationDiversityGenetic featuresAncestryPolygenic scoresMiddle East populationLociPopulationPeculiar genetic featuresGenetic predispositionHuman groupsLarge numberTurkish populationLast finding
2014
GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations
Karaca S, Karaca M, Cesuroglu T, Erge S, Polimanti R. GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations. American Journal Of Human Biology 2014, 27: 310-316. PMID: 25515186, DOI: 10.1002/ajhb.22671.Peer-Reviewed Original ResearchConceptsHuman Genome Diversity ProjectGenetic association studiesSequence variationAssociation studiesFunctional variantsHigh linkage disequilibriumFuture genetic association studiesWorldwide populationCommon functional variantsGenetic diversityGenetic variabilityGenome ProjectOxidative stress-related diseasesGST genesLinkage disequilibriumEastern populationsDiversity ProjectGSTP1 functionStress-related diseasesStudy of diseasesGenetic polymorphismsSequenom MassARRAY platformPolymorphismVariantsGlutathione S-transferase variants