Featured Publications
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome. Nature Human Behaviour 2020, 5: 482-496. PMID: 33349686, PMCID: PMC8068566, DOI: 10.1038/s41562-020-00980-y.Peer-Reviewed Original ResearchConceptsPsychosocial factorsSocioeconomic statusPsychiatric disordersBipolar disorderGenetic riskNeuronal cell typesMajor depressionTourette syndromeBrain morphologyDisordersImaging phenotypesCell typesRisky behaviorsPsychopathologyGenetic overlapRiskGenetic discoveriesPsychiatric traitsStatusSyndrome
2025
A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases
Lukas E, Veeneman R, Smit D, Ahluwalia T, Vermeulen J, Pathak G, Polimanti R, Verweij K, Treur J. A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. Translational Psychiatry 2025, 15: 1. PMID: 39755697, PMCID: PMC11700205, DOI: 10.1038/s41398-024-03197-z.Peer-Reviewed Original ResearchPosttraumatic stress disorderMendelian randomizationCardiovascular diseaseCausal pathwaysData of genome-wide association studiesGenetic liabilityMultivariable Mendelian randomizationWaist-to-hip ratioPotential mediatorsWaist-to-hipRisk of cardiovascular diseaseGenome-wide association studiesPotential causal pathwaysPrevent cardiovascular diseaseStress disorderIncreased risk of cardiovascular diseaseGenomic structural equationSignificant genetic correlationsPsychosocial factorsEffects of posttraumatic stress disorderAssociation studiesIncreased riskPosttraumatic stress disorder patientsCausal effectsTraumatic events
2023
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scoreGenetic predispositionModifiable psychosocial variablesAge-related morbidityGamma-glutamyl transferaseInflammatory biomarkersSystemic inflammationNational HealthApolipoprotein BMale veteransPsychosocial factorsVeterans StudySaliva samplesPsychosocial moderatorsPsychosocial variablesAntihistamine drugsMilitary veteransGrimAgeGrimAge accelerationInflammationUK BiobankDrugsRepresentative samplePredisposition