2022
Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women
Carvalho CM, Coimbra BM, Xavier G, Bugiga AVG, Fonseca T, Olff M, Polimanti R, Mello AF, Ota VK, Mello MF, Belangero SI. Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women. Frontiers In Psychiatry 2022, 13: 835783. PMID: 35664481, PMCID: PMC9161278, DOI: 10.3389/fpsyt.2022.835783.Peer-Reviewed Original ResearchPosttraumatic stress disorderRe-experiencing symptomsPolymerase chain reactionMini International Neuropsychiatric InterviewClinician-Administered PTSD ScaleInternational Neuropsychiatric InterviewPTSD re-experiencing symptomsReal-time polymerase chain reactionCivilian womenMultiplex real-time polymerase chain reactionRemitter patientsShorter leukocyteBaseline LTLNeuropsychiatric InterviewPrevious historyPTSD ScaleMental disordersPTSD diagnosisSymptomsStress disorderPTSD casesPTSD symptomsTime pointsWomenChain reaction
2017
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers
Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatrica Scandinavica 2017, 137: 148-156. PMID: 29230810, PMCID: PMC6110087, DOI: 10.1111/acps.12843.Peer-Reviewed Original ResearchConceptsBD polygenic risk scorePolygenic risk scoresAlcohol misuseBipolar disorderTrauma exposurePsychiatric disordersGenetic riskMajor depressive disorderNicotine dependence symptomsSubstance use disordersSchizophrenia polygenic risk scoresVoltage-gated calcium channel activityCalcium channel activityUS Army soldiersBeta2-adrenergic receptorDepressive disorderRisk scoreUse disordersAdrenergic receptorsMental disordersSubstance abuseDisordersDependence symptomsChannel activityExposure
2016
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016, 73: 695-704. PMID: 27167565, PMCID: PMC4936936, DOI: 10.1001/jamapsychiatry.2016.0350.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsCase-Control StudiesChromosomes, Human, Pair 19Chromosomes, Human, Pair 5Cohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMilitary PersonnelPolymorphism, Single NucleotideStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderTrauma-exposed controlsNew Soldier StudyRheumatoid arthritisStress disorderLifetime posttraumatic stress disorderSerious public health concernUnique participantsImmune-related disordersCumulative trauma exposureGenetic risk factorsPublic health concernLogistic regression modelsUS Army soldiersGenome-wide association studiesInflammatory disordersLifetime riskRisk factorsMAIN OUTCOMEPrimary analysisPost Deployment StudyAssociation studiesControl individualsMental disordersSignificant association