2012
Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women
Polimanti R, Piacentini S, Lazzarin N, Vaquero E, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertility And Sterility 2012, 98: 396-400. PMID: 22633257, DOI: 10.1016/j.fertnstert.2012.05.003.Peer-Reviewed Original ResearchConceptsRecurrent miscarriageT alleleRisk of RMGSTA1 geneGlutathione S-transferaseGSTM1 variantsPregnancy complicationsRM riskMAIN OUTCOMEGST polymorphismsRM groupNull genotypeControl groupGSTT1 genesSignificant associationGSTP1 geneBuccal cellsItalian womenDifferent genetic modelsSingle nucleotide polymorphismsWomenGSTA1MiscarriageRiskGenetic association studiesGSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients
Piacentini S, Polimanti R, Squitti R, Ventriglia M, Cassetta E, Vernieri F, Rossini PM, Manfellotto D, Fuciarelli M. GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. Journal Of The Neurological Sciences 2012, 317: 137-140. PMID: 22381228, DOI: 10.1016/j.jns.2012.01.026.Peer-Reviewed Original ResearchConceptsGSTM1 null genotypeAlzheimer's diseaseNull genotypeRisk factorsItalian patientsCause of ADLate-onset Alzheimer's diseaseLogistic regression analysisGlutathione S-transferaseCase-control populationAD patientsAD riskGSTM1 geneGSTT1 genesGenotype distributionDisease riskNeurodegenerative disordersDiseasePatientsOxidative stressEndogenous metabolitesCommon formRegression analysisPositive associationGSTM1Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy.
Piacentini S, Polimanti R, Moscatelli B, Re MA, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. Journal Of Investigational Allergology And Clinical Immunology 2012, 22: 252-6. PMID: 22812193.Peer-Reviewed Original ResearchConceptsDevelopment of asthmaAsthma developmentPolymerase chain reactionGSTP1 polymorphismsGlutathione S-transferaseGene polymorphismsOxidative stressGST gene polymorphismsLack of associationGSTT1 gene polymorphismsComplex multifactorial diseasePCR-restriction fragment length polymorphism analysisAsthmatic patientsAdult patientsAsthma pathogenesisInflammatory responseAsthma riskGST polymorphismsAsthmaMultiplex polymerase chain reactionHealthy individualsAntioxidant defense systemGSTT1 genesMultifactorial diseaseUnrelated healthy individuals
2010
Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study
Piacentini S, Polimanti R, Moscatelli B, Re MA, Fuciarelli R, Manfellotto D, Fuciarelli M. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. Annals Of Human Biology 2010, 37: 427-439. PMID: 20367187, DOI: 10.3109/03014461003636419.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase (GST) gene polymorphismsImpairs pulmonary functionCommon chronic diseasesCase-control studyGlutathione S-transferaseGenotyping of GSTM1Interactive risk factorsFrequency of GSTA1Asthmatic patientsPulmonary functionAsthma developmentRisk factorsChronic diseasesGSTT1 genotypeGSTP1 polymorphismsPCR-RFLP methodAsthma diseaseGene-environment interactionsControl groupGene polymorphismsGSTT1 genesPossible associationReactive oxygen speciesProtection of cellsAsthma