2023
Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data
Quintero Reis A, Newton B, Kessler R, Polimanti R, Wendt F. Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data. Molecular Psychiatry 2023, 28: 1064-1071. PMID: 36604601, PMCID: PMC10005939, DOI: 10.1038/s41380-022-01929-5.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic scoringSummary association dataGenome-wide dataSNP effect sizesGenomic structural equation modelingGenetic study designsNew traitsAdmixed AmericansEffect size distributionBiological pathwaysAssociation studiesTranscriptomic featuresMolecular characterizationSusceptibility lociGenetic correlationsAssociation dataWide dataTraitsGenetic contributionEuropean ancestryCommon genetic factorsLociPhenotypeGenetic factors
2021
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates
Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates. Neuropsychopharmacology 2021, 47: 1739-1745. PMID: 34750568, PMCID: PMC9372072, DOI: 10.1038/s41386-021-01209-w.Peer-Reviewed Original Research