2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposure
2023
Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder
Smith K, Lacadie C, Milivojevic V, Fogelman N, Sinha R. Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder. Drug And Alcohol Dependence 2023, 244: 109794. PMID: 36758371, PMCID: PMC10024802, DOI: 10.1016/j.drugalcdep.2023.109794.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug cuesFuture drug useDrug use daysCue exposureNeural responsesUse daysSex differencesVentromedial prefrontal cortexScript-driven imageryDrug cue exposureNeutral cue exposureWhole-brain analysisWhole-brain correlationUse disordersDrug use outcomesCue-induced anxietyBrain responsesHeart rateFMRI scansPrefrontal cortexDrug cravingDrug useBrain analysisBrain correlations