2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllness
2007
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray G, Corlett P, Clark L, Pessiglione M, Blackwell A, Honey G, Jones P, Bullmore E, Robbins T, Fletcher P. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 2007, 13: 267-276. PMID: 17684497, PMCID: PMC2564111, DOI: 10.1038/sj.mp.4002058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCase-Control StudiesChoice BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, PsychologicalNeuropsychological TestsOxygenPhotic StimulationPsychiatric Status Rating ScalesPsychotic DisordersRewardSubstantia NigraVentral Tegmental AreaConceptsDopaminergic midbrainFunctional magnetic resonance imagingReward prediction errorHealthy control participantsPsychosis patientsNeutral stimuliMotivational salienceNeural responsesMental experienceRecent theoretical interestFirst-episode psychosis patientsPrediction errorConditioning experimentsControl participantsEpisode psychosis patientsPsychotic experiencesPathophysiology of schizophreniaPositive symptomsAbnormal physiological responsesMesolimbic activityMidbrain dopamine neuronsMagnetic resonance imagingDopamine dysfunctionDopamine systemDopamine neurons