NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modelingCognition-Emotion Dysinteraction in Schizophrenia
Anticevic A, Corlett PR. Cognition-Emotion Dysinteraction in Schizophrenia. Frontiers In Psychology 2012, 3: 392. PMID: 23091464, PMCID: PMC3470461, DOI: 10.3389/fpsyg.2012.00392.Peer-Reviewed Original ResearchNeural systemsSpecific emotional processesNon-emotional stimuliRole of affectComplex behavioral symptomsEmotional informationAffective informationCognitive operationsEmotional processesMotivational abnormalitiesTheory of schizophreniaIntact abilityNeurobiology of schizophreniaProspective valuationCognitive deficitsCurrent theoretical modelsAffective operationsExplanatory gapBelief formationSymptom domainsEmotional functionBehavioral symptomsNeural circuitsCognitionStimuli