2019
Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence
Nunes EJ, Bitner L, Hughley SM, Small KM, Walton SN, Rupprecht LE, Addy NA. Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence. Neuroscience 2019, 413: 252-263. PMID: 31271832, PMCID: PMC6661179, DOI: 10.1016/j.neuroscience.2019.06.028.Peer-Reviewed Original ResearchConceptsCue-induced cocaineAnxiety-related behaviorDrug relapseOpen arm timeCholinergic receptor blockadeCocaine abstinenceVentral tegmental areaSubstance abuseSelf-administer intravenous cocaineMuscarinic receptor antagonist scopolaminePeriod of abstinenceAnxiogenic effectsReceptor blockadeCholinergic mechanismsCocaine-naïve ratsNicotinic acetylcholine receptor antagonist mecamylamineMale Sprague-Dawley ratsDrug abstinenceSprague-Dawley ratsDose-dependent increaseCocaine-naive ratsAntagonist scopolamineEPM behaviorSaline ratsAbstinence
2002
Hippocampal α7 and α4β2 nicotinic receptors and working memory
Levin E, Bradley A, Addy N, Sigurani N. Hippocampal α7 and α4β2 nicotinic receptors and working memory. Neuroscience 2002, 109: 757-765. PMID: 11927157, DOI: 10.1016/s0306-4522(01)00538-3.Peer-Reviewed Original ResearchConceptsDH beta EAlpha 7 nicotinic receptorAlpha 4 beta 2Ventral hippocampusNicotinic receptorsLow dosesBeta EReference memory errorsCounter-balanced orderRadial mazeHigh dosesAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsNicotine-induced memory improvementAcute intrahippocampal infusionsVentral hippocampal infusionsBeta 2Nicotinic receptor blockadeNicotinic receptor agonistsSprague-Dawley ratsΑ4β2 nicotinic receptorsSignificant increaseChronic guide cannulaeHippocampal α7Nicotinic involvement
2001
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats
Levin E, Addy N, Nakajima A, Christopher N, Seidler F, Slotkin T. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Research 2001, 130: 83-89. PMID: 11557096, DOI: 10.1016/s0165-3806(01)00215-2.Peer-Reviewed Original ResearchConceptsFigure-8 apparatusPostnatal CPF exposureCPF exposureEarly neonatal exposureMuscarinic cholinergic controlNeonatal chlorpyrifos exposurePersistent behavioral effectsRadial mazeT-mazeNicotinic cholinergic antagonistBrain cell developmentReference memory impairmentRadial arm mazeReference memory errorsPNDs 11Neonatal exposurePND 1Muscarinic antagonistNeonatal periodCholinergic antagonistsCholinergic controlNeurochemical changesRate of habituationCPF groupLong-term effects