Altered hippocampal interneuron activity precedes ictal onset
Miri ML, Vinck M, Pant R, Cardin J. Altered hippocampal interneuron activity precedes ictal onset. ELife 2018, 7: e40750. PMID: 30387711, PMCID: PMC6245730, DOI: 10.7554/elife.40750.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsElectroencephalographyHippocampusInterneuronsMiceOptogeneticsSeizuresConceptsSynaptic inhibitionIctal activityEarly ictal phaseHippocampal interneuron activityLocal circuit interactionsSomatostatin-expressing (SST) interneuronsInhibitory interneuron populationsSeizure inductionGABAergic inhibitionSeizure disorderIctal onsetSource of inhibitionSeizure initiationIctal phaseHippocampal circuitsInterneuron activityInterneuron populationsInterneuron classesFiring patternsInterneuronsElectrophysiological approachesPreictal periodInhibitionParvalbuminOnset