Stable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics
Feng G, Gao M, Chen H, Zhang Z, Chen J, Tong Y, Wu P, Fu R, Lin Y, Chen S. Stable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics. Analytical Chemistry 2024, 96: 2524-2533. PMID: 38308578, DOI: 10.1021/acs.analchem.3c04824.Peer-Reviewed Original ResearchConceptsC-C bondsAccurate lipid quantificationAccurate relative quantificationOne-step introductionLipid isomersC bondSimultaneous qualificationLarge-scale resolutionMouse brain ischemiaStructural resolutionRelative quantificationUnsaturated lipidsLipid quantificationAccurate quantificationBrain ischemiaIsomersQuantificationActive groupEsterReactionPositive identificationPathological processesCholesterol estersLipidomics