Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS
Dai M, Dou X, Chen M, Yang J, Long J, Lin Y. Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS. Naunyn-Schmiedeberg's Archives Of Pharmacology 2023, 397: 4105-4121. PMID: 38032491, DOI: 10.1007/s00210-023-02844-4.Peer-Reviewed Original ResearchAcute adverse drug reactionsEmpirical Bayesian geometric meanAdverse eventsSystem organ classReporting odds ratioProportional reporting ratioAdverse Event Reporting System databaseFDA Adverse Event Reporting System (FAERS) databaseSevere cancer painAdverse drug reactionsNervous system disordersReal-world studyUS FDA Adverse Event Reporting System (FAERS) databaseReporting System databasePostoperative analgesiaCancer painRespiratory depressionChronic painToxic leukoencephalopathyGeneral anesthesiaMediastinal diseaseDrug reactionsMediastinal disordersOdds ratioRespiratory disorders