Featured Publications
Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence
Gee DG, Sisk LM, Cohodes EM, Bryce NV. Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence. Nature Communications 2022, 13: 5693. PMID: 36171218, PMCID: PMC9519553, DOI: 10.1038/s41467-022-33416-4.Peer-Reviewed Original ResearchNeural effects of controllability as a key dimension of stress exposure
Cohodes EM, Odriozola P, Mandell JD, Caballero C, McCauley S, Zacharek SJ, Hodges HR, Haberman JT, Smith M, Thomas J, Meisner OC, Ellis CT, Hartley CA, Gee DG. Neural effects of controllability as a key dimension of stress exposure. Development And Psychopathology 2022, 35: 218-227. PMID: 35034670, DOI: 10.1017/s0954579421001498.Peer-Reviewed Original ResearchConceptsDorsal anterior insulaRight dorsal anterior insulaUncontrollable stress conditionUncontrollable stressStress exposureSex-matched participantsStressor controllabilityInitial exposureFunctional magnetic resonance imaging (fMRI) acquisitionSubsequent stress exposureNeural effectsAnterior insulaYoung adultsSubsequent stressorsPatterns of activityCross-species evidenceNeural correlatesSubsequent exposureExposureNeural underpinningsPresent studyParticipantsMagnetic resonance imaging (MRI) acquisitionAdaptive responseFMRI analysisEarly Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience
Gee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.Peer-Reviewed Original ResearchConceptsEarly adversityProtective factorsEffects of adversityOnset of psychopathologyPathways of riskNeurodevelopmental trajectoriesMajor risk factorAdversityMental healthNeurodevelopmental pathwaysEarly environmentPsychopathologySpecific dimensionsIntervention strategiesFuture researchRisk factorsEarly risk identificationTreatment approachesImmense burdenConceptual modelDevelopmental timingResilienceOngoing refinementRiskFactorsAssociations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
Brieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNegative life eventsLife eventsInternalizing symptomsAdversity exposureCortico-limbic connectivityParental acceptanceAdolescent Brain Cognitive Development (ABCD) studyLongitudinal structural equation modelLower internalizing symptomsCognitive Development StudyContext of adversityIndirect effectsSample of youthStressful childhood experiencesCortico-limbic networkStructural equation modelLater psychopathologyNeurobiological maturationInternalizing problemsABCD studyFunctional connectivityChildhood experiencesPotential protective effectPsychopathology
2024
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Gross R, Thaweethai T, Rosenzweig E, Chan J, Chibnik L, Cicek M, Elliott A, Flaherman V, Foulkes A, Witvliet M, Gallagher R, Gennaro M, Jernigan T, Karlson E, Katz S, Kinser P, Kleinman L, Lamendola-Essel M, Milner J, Mohandas S, Mudumbi P, Newburger J, Rhee K, Salisbury A, Snowden J, Stein C, Stockwell M, Tantisira K, Thomason M, Truong D, Warburton D, Wood J, Ahmed S, Akerlundh A, Alshawabkeh A, Anderson B, Aschner J, Atz A, Aupperle R, Baker F, Balaraman V, Banerjee D, Barch D, Baskin-Sommers A, Bhuiyan, Bind M, Bogie A, Bradford T, Buchbinder N, Bueler E, Bükülmez H, Casey B, Chang L, Chrisant M, Clark D, Clifton R, Clouser K, Cottrell L, Cowan K, D’Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer K, Elias M, Esquenazi-Karonika S, Evans D, Faustino E, Fiks A, Forsha D, Foxe J, Friedman N, Fry G, Gaur S, Gee D, Gray K, Handler S, Harahsheh A, Hasbani K, Heath A, Hebson C, Heitzeg M, Hester C, Hill S, Hobart-Porter L, Hong T, Horowitz C, Hsia D, Huentelman M, Hummel K, Irby K, Jacobus J, Jacoby V, Jone P, Kaelber D, Kasmarcak T, Kluko M, Kosut J, Laird A, Landeo-Gutierrez J, Lang S, Larson C, Lim P, Lisdahl K, McCrindle B, McCulloh R, McHugh K, Mendelsohn A, Metz T, Miller J, Mitchell E, Morgan L, Müller-Oehring E, Nahin E, Neale M, Ness-Cochinwala M, Nolan S, Oliveira C, Osakwe O, Oster M, Payne R, Portman M, Raissy H, Randall I, Rao S, Reeder H, Rosas J, Russell M, Sabati A, Sanil Y, Sato A, Schechter M, Selvarangan R, Tejtel S, Shakti D, Sharma K, Squeglia L, Srivastava S, Stevenson M, Szmuszkovicz J, Talavera-Barber M, Teufel R, Thacker D, Trachtenberg F, Udosen M, Warner M, Watson S, Werzberger A, Weyer J, Wood M, Yin H, Zempsky W, Zimmerman E, Dreyer B, Consortium O. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLOS ONE 2024, 19: e0285635. PMID: 38713673, PMCID: PMC11075869, DOI: 10.1371/journal.pone.0285635.Peer-Reviewed Original ResearchConceptsYoung adultsClinical courseAdolescent Brain Cognitive DevelopmentCaregiver-child pairsLong-term outcomesObservational cohort studyOutcomes of COVID-19De novo cohortAdolescent Brain Cognitive Development StudySociodemographic correlatesCommunity partnersBaseline assessmentLongitudinal follow-upPotential therapeutic interventionsPediatric protocolsCohort studyCollaborative partnershipsProspective cohortFollow-upStudy protocolFederal partnersNIH Researching COVIDLong-term outcomes of COVID-19Enhanced recoveryData collectionResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Meta-Analytic Evidence for Association of Adversity With Brain Function
Gee D, Brieant A. Meta-Analytic Evidence for Association of Adversity With Brain Function. JAMA Network Open 2023, 6: e2339966. PMID: 37910108, DOI: 10.1001/jamanetworkopen.2023.39966.Peer-Reviewed Original Research
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratioFamily accommodation in pediatric anxiety: Relations with avoidance and self-efficacy
Kitt ER, Lewis KM, Galbraith J, Abend R, Smith AR, Lebowitz ER, Pine DS, Gee DG. Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy. Behaviour Research And Therapy 2022, 154: 104107. PMID: 35613517, PMCID: PMC9271364, DOI: 10.1016/j.brat.2022.104107.Peer-Reviewed Original ResearchConceptsFamily accommodationPediatric anxietyAnxiety disordersNon-anxious controlsClinician ratingsPediatric anxiety disordersReal-world behaviorImportant preliminary insightsBody of researchLaboratory tasksMediation modelGreater avoidanceAge 8AnxietyDistinct measuresUntested relationsFuture researchYouthRobust associationAvoidanceBehavioral factorsRatingsPreliminary insightsEarly identificationDisordersThe role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach.
Conley MI, Hernandez J, Salvati JM, Gee DG, Baskin-Sommers A. The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach. Development And Psychopathology 2022, 35: 689-710. PMID: 35232507, PMCID: PMC9437149, DOI: 10.1017/s095457942100184x.Peer-Reviewed Original ResearchConceptsMental healthAdolescent Brain Cognitive DevelopmentDisruptive behavior symptomsLatent profile analysisPerception of threatPerson-centered approachPoor mental healthCognitive developmentDevelopmental pictureYouth outcomesNeurocognitive difficultiesYouth perceptionsBehavior symptomsSleep problemsLow threatAge 9Age 11Neurocognitive outcomesMultiple domainsMultiple contextsYouth’s neighborhoodsOutcomes 2 yearsDistinct profilesPerceptionYouth environmentTraining the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action
Gee DG, DeYoung KA, McLaughlin KA, Tillman RM, Barch DM, Forbes EE, Krueger RF, Strauman TJ, Weierich MR, Shackman AJ. Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action. Annual Review Of Clinical Psychology 2022, 18: 43-70. PMID: 35216523, PMCID: PMC9086080, DOI: 10.1146/annurev-clinpsy-081219-092500.Peer-Reviewed Original ResearchConceptsClinical psychologyClinical psychological scientistsPsychological scientistsMental health conditionsCurrent training practicesMental healthSubstance useIntervention strategiesPsychologyTraining practicesClinical scientistsMental disordersGlobal public healthCentral goalImmense burdenSpecific recommendationsAnxietyPersonalityHealth conditionsMoodScientific rigorPublic healthPsychosisHealthBurdenExperimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2021
When do sensitive periods emerge later in development?
Gee DG. When do sensitive periods emerge later in development? Trends In Cognitive Sciences 2021, 26: 97-98. PMID: 34933793, DOI: 10.1016/j.tics.2021.12.001.Peer-Reviewed Original ResearchStress and adolescence: vulnerability and opportunity during a sensitive window of development
Sisk LM, Gee DG. Stress and adolescence: vulnerability and opportunity during a sensitive window of development. Current Opinion In Psychology 2021, 44: 286-292. PMID: 34818623, PMCID: PMC9007828, DOI: 10.1016/j.copsyc.2021.10.005.Peer-Reviewed Original ResearchGenetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivityMigration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy
Cohodes EM, Kribakaran S, Odriozola P, Bakirci S, McCauley S, Hodges HR, Sisk LM, Zacharek SJ, Gee DG. Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy. Developmental Psychobiology 2021, 63: e22158. PMID: 34292596, PMCID: PMC8410670, DOI: 10.1002/dev.22158.Peer-Reviewed Original ResearchConceptsMental healthMigration-related traumaEffects of traumaDevelopment of internalizingEarly life adversityEmotion regulationMigrant childrenTransdiagnostic mechanismsTrauma exposureExternalizing symptomatologyTraumatic experiencesRefugee childrenChildren's exposureDevelopmental neurobiologyChildrenYouthInterdisciplinary effortInternalizingTraumaImplicationsAdversityNeurobiologyContext of migrationSymptomatologyLearningLeveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiologyResponsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study
Simmons C, Conley MI, Gee DG, Baskin-Sommers A, Barch DM, Hoffman EA, Huber RS, Iacono WG, Nagel BJ, Palmer CE, Sheth CS, Sowell ER, Thompson WK, Casey BJ. Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study. Psychological Science 2021, 32: 866-870. PMID: 34043478, PMCID: PMC8726588, DOI: 10.1177/09567976211003564.Peer-Reviewed Original ResearchParental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth Symptomatology
Cohodes EM, McCauley S, Gee DG. Parental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth Symptomatology. Research On Child And Adolescent Psychopathology 2021, 49: 935-948. PMID: 33591457, PMCID: PMC7885749, DOI: 10.1007/s10802-020-00732-6.Peer-Reviewed Original ResearchConceptsPandemic-related stressChild symptomatologyAnxiety-related symptomatologyYouth symptomatologyFamily-level factorsCross-sectional study designCOVID-19-related stressYouth mental healthEffects of exposureParental bufferingStudy designSymptomatologyMental healthChildren's exposureParental reportsHigh levelsCOVID-19COVID-19 pandemicNegative emotionsGlobal pandemicDegree of stressExposureLight of evidenceHome routinesParenting stressDecomposing complex links between the childhood environment and brain structure in school-aged youth
Hong SJ, Sisk LM, Caballero C, Mekhanik A, Roy AK, Milham MP, Gee DG. Decomposing complex links between the childhood environment and brain structure in school-aged youth. Developmental Cognitive Neuroscience 2021, 48: 100919. PMID: 33556882, PMCID: PMC7868609, DOI: 10.1016/j.dcn.2021.100919.Peer-Reviewed Original ResearchConceptsSupportive caregivingAdolescent Brain Cognitive Development (ABCD) studyOverall mental health problemsCross-modal integrationHigh family conflictCognitive Development StudyBrain structuresDistinct environmental exposuresSchool-aged youthMental health problemsSchool-aged childrenGreater cortical thicknessExternalizing symptomsFamily conflictGreater myelinationBehavioral developmentBrain morphometricsStructural neurodevelopmentChildhood experiencesProtective factorsOptimize interventionsNeighborhood safetyDifferent facetsSchool environmentSpecific experiences