2024
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Gross R, Thaweethai T, Rosenzweig E, Chan J, Chibnik L, Cicek M, Elliott A, Flaherman V, Foulkes A, Witvliet M, Gallagher R, Gennaro M, Jernigan T, Karlson E, Katz S, Kinser P, Kleinman L, Lamendola-Essel M, Milner J, Mohandas S, Mudumbi P, Newburger J, Rhee K, Salisbury A, Snowden J, Stein C, Stockwell M, Tantisira K, Thomason M, Truong D, Warburton D, Wood J, Ahmed S, Akerlundh A, Alshawabkeh A, Anderson B, Aschner J, Atz A, Aupperle R, Baker F, Balaraman V, Banerjee D, Barch D, Baskin-Sommers A, Bhuiyan, Bind M, Bogie A, Bradford T, Buchbinder N, Bueler E, Bükülmez H, Casey B, Chang L, Chrisant M, Clark D, Clifton R, Clouser K, Cottrell L, Cowan K, D’Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer K, Elias M, Esquenazi-Karonika S, Evans D, Faustino E, Fiks A, Forsha D, Foxe J, Friedman N, Fry G, Gaur S, Gee D, Gray K, Handler S, Harahsheh A, Hasbani K, Heath A, Hebson C, Heitzeg M, Hester C, Hill S, Hobart-Porter L, Hong T, Horowitz C, Hsia D, Huentelman M, Hummel K, Irby K, Jacobus J, Jacoby V, Jone P, Kaelber D, Kasmarcak T, Kluko M, Kosut J, Laird A, Landeo-Gutierrez J, Lang S, Larson C, Lim P, Lisdahl K, McCrindle B, McCulloh R, McHugh K, Mendelsohn A, Metz T, Miller J, Mitchell E, Morgan L, Müller-Oehring E, Nahin E, Neale M, Ness-Cochinwala M, Nolan S, Oliveira C, Osakwe O, Oster M, Payne R, Portman M, Raissy H, Randall I, Rao S, Reeder H, Rosas J, Russell M, Sabati A, Sanil Y, Sato A, Schechter M, Selvarangan R, Tejtel S, Shakti D, Sharma K, Squeglia L, Srivastava S, Stevenson M, Szmuszkovicz J, Talavera-Barber M, Teufel R, Thacker D, Trachtenberg F, Udosen M, Warner M, Watson S, Werzberger A, Weyer J, Wood M, Yin H, Zempsky W, Zimmerman E, Dreyer B, Consortium O. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLOS ONE 2024, 19: e0285635. PMID: 38713673, PMCID: PMC11075869, DOI: 10.1371/journal.pone.0285635.Peer-Reviewed Original ResearchConceptsYoung adultsClinical courseAdolescent Brain Cognitive DevelopmentCaregiver-child pairsLong-term outcomesObservational cohort studyOutcomes of COVID-19De novo cohortAdolescent Brain Cognitive Development StudySociodemographic correlatesCommunity partnersBaseline assessmentLongitudinal follow-upPotential therapeutic interventionsPediatric protocolsCohort studyCollaborative partnershipsProspective cohortFollow-upStudy protocolFederal partnersNIH Researching COVIDLong-term outcomes of COVID-19Enhanced recoveryData collectionResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratioFamily accommodation in pediatric anxiety: Relations with avoidance and self-efficacy
Kitt ER, Lewis KM, Galbraith J, Abend R, Smith AR, Lebowitz ER, Pine DS, Gee DG. Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy. Behaviour Research And Therapy 2022, 154: 104107. PMID: 35613517, PMCID: PMC9271364, DOI: 10.1016/j.brat.2022.104107.Peer-Reviewed Original ResearchConceptsFamily accommodationPediatric anxietyAnxiety disordersNon-anxious controlsClinician ratingsPediatric anxiety disordersReal-world behaviorImportant preliminary insightsBody of researchLaboratory tasksMediation modelGreater avoidanceAge 8AnxietyDistinct measuresUntested relationsFuture researchYouthRobust associationAvoidanceBehavioral factorsRatingsPreliminary insightsEarly identificationDisorders
2021
Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy
Cohodes EM, Kribakaran S, Odriozola P, Bakirci S, McCauley S, Hodges HR, Sisk LM, Zacharek SJ, Gee DG. Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy. Developmental Psychobiology 2021, 63: e22158. PMID: 34292596, PMCID: PMC8410670, DOI: 10.1002/dev.22158.Peer-Reviewed Original ResearchConceptsMental healthMigration-related traumaEffects of traumaDevelopment of internalizingEarly life adversityEmotion regulationMigrant childrenTransdiagnostic mechanismsTrauma exposureExternalizing symptomatologyTraumatic experiencesRefugee childrenChildren's exposureDevelopmental neurobiologyChildrenYouthInterdisciplinary effortInternalizingTraumaImplicationsAdversityNeurobiologyContext of migrationSymptomatologyLearningLeveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiologyParental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth Symptomatology
Cohodes EM, McCauley S, Gee DG. Parental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth Symptomatology. Research On Child And Adolescent Psychopathology 2021, 49: 935-948. PMID: 33591457, PMCID: PMC7885749, DOI: 10.1007/s10802-020-00732-6.Peer-Reviewed Original ResearchConceptsPandemic-related stressChild symptomatologyAnxiety-related symptomatologyYouth symptomatologyFamily-level factorsCross-sectional study designCOVID-19-related stressYouth mental healthEffects of exposureParental bufferingStudy designSymptomatologyMental healthChildren's exposureParental reportsHigh levelsCOVID-19COVID-19 pandemicNegative emotionsGlobal pandemicDegree of stressExposureLight of evidenceHome routinesParenting stressDecomposing complex links between the childhood environment and brain structure in school-aged youth
Hong SJ, Sisk LM, Caballero C, Mekhanik A, Roy AK, Milham MP, Gee DG. Decomposing complex links between the childhood environment and brain structure in school-aged youth. Developmental Cognitive Neuroscience 2021, 48: 100919. PMID: 33556882, PMCID: PMC7868609, DOI: 10.1016/j.dcn.2021.100919.Peer-Reviewed Original ResearchConceptsSupportive caregivingAdolescent Brain Cognitive Development (ABCD) studyOverall mental health problemsCross-modal integrationHigh family conflictCognitive Development StudyBrain structuresDistinct environmental exposuresSchool-aged youthMental health problemsSchool-aged childrenGreater cortical thicknessExternalizing symptomsFamily conflictGreater myelinationBehavioral developmentBrain morphometricsStructural neurodevelopmentChildhood experiencesProtective factorsOptimize interventionsNeighborhood safetyDifferent facetsSchool environmentSpecific experiencesDevelopment and Validation of the Parental Assistance with Child Emotion Regulation (PACER) Questionnaire
Cohodes EM, Preece DA, McCauley S, Rogers MK, Gross JJ, Gee DG. Development and Validation of the Parental Assistance with Child Emotion Regulation (PACER) Questionnaire. Research On Child And Adolescent Psychopathology 2021, 50: 133-148. PMID: 33411232, DOI: 10.1007/s10802-020-00759-9.Peer-Reviewed Original ResearchConceptsEmotion regulatory strategiesChildren's emotion regulationEmotion regulationRegulation strategiesPoorer parent-child relationship qualityParent-child relationship qualityEmotion regulation strategiesEmotion Regulation QuestionnaireTen-factor structureParental assistanceDifferent regulation strategiesDifferent child agesHigher child internalizingRegulatory strategiesAcceptable test-retest reliabilityConfirmatory factor analysisExcellent internal consistencyEmotion sensitivityChild executionNegative emotionsExternalizing problemsTest-retest reliabilityChild stressPsychometric measuresChildren's internalizing
2020
Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortex
2019
Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions
Kribakaran S, Danese A, Bromis K, Kempton MJ, Gee DG. Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 23-34. PMID: 31690501, PMCID: PMC6954289, DOI: 10.1016/j.bpsc.2019.08.006.Peer-Reviewed Original ResearchConceptsPediatric PTSDPediatric posttraumatic stress disorderPTSD groupTrauma exposurePosttraumatic stress disorderHippocampal volumeVolumetric brain differencesStructural magnetic resonance imaging (MRI) studiesStructural brain volumesMagnetic resonance imaging studyResonance imaging studySmaller total gray matterPediatric anxietyPosttraumatic stressAnxiety groupStress disorderNeurobiological differencesBrain differencesSmaller hippocampal volumesPediatric psychiatric conditionsTemporal lobeEffect of agePediatric depressionPsychiatric conditionsComparison groupA call for action on migrant children's mental health
Gee DG, Cohodes EM. A call for action on migrant children's mental health. The Lancet Psychiatry 2019, 6: 286. PMID: 30904123, DOI: 10.1016/s2215-0366(19)30094-x.Peer-Reviewed Original ResearchNovel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood
Cohodes EM, Abusch A, Odriozola P, Gee DG. Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood. Clinical Child Psychology And Psychiatry 2019, 25: 189-199. PMID: 30696260, PMCID: PMC6667310, DOI: 10.1177/1359104518822685.Peer-Reviewed Original ResearchConceptsSleep quantitySleep-related interventionsSleep functionPredictors of anxietyPediatric clinical samplesAge-related changesHigh anxietyAnxietyPediatric samplesPrevious researchSleep dysfunctionClinical samplesChildhoodFunction changesAdolescenceAdolescentsActigraphyPresent studyYouthQuantitative measuresCorrelatesAssociationSleepChildrenIntervention
2018
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderRostral anterior cingulate cortexFunctional connectivityTD individualsDifferent age-related patternsResting-state functional connectivityOverall group differencesBroad developmental rangeAnterior cingulate cortexSocioemotional functioningSocioemotional impairmentsSpectrum disorderCross-sectional sampleAge-related changesRight basolateral amygdalaCingulate cortexAge-related patternsGroup differencesDevelopmental rangeFrontoamygdala circuitryBasolateral amygdalaAmygdalaIndividualsPrior workImpairmentNeurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence
Gee DG, Bath KG, Johnson CM, Meyer HC, Murty VP, van den Bos W, Hartley CA. Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence. Journal Of Neuroscience 2018, 38: 9433-9445. PMID: 30381435, PMCID: PMC6209847, DOI: 10.1523/jneurosci.1674-18.2018.Peer-Reviewed Original ResearchConceptsMotivated behaviorProcessing of threatReward-motivated behaviorsNeural circuitsEarly life stressCognitive processesCourse of developmentDevelopmental trajectoriesExperiential factorsNeurocognitive developmentAdaptive behaviorRecent methodological innovationsDevelopmental changesDevelopmental onsetRecent researchPsychiatric disordersAdulthoodMethodological innovationsAdolescenceNeurocircuitryRewardBehaviorResearchChildhoodProcessingImplications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach
2017
Development of the emotional brain
Casey BJ, Heller AS, Gee DG, Cohen AO. Development of the emotional brain. Neuroscience Letters 2017, 693: 29-34. PMID: 29197573, PMCID: PMC5984129, DOI: 10.1016/j.neulet.2017.11.055.Peer-Reviewed Original ResearchConceptsEmotion reactivityEmotional brainCognitive control circuitryNeurobiological accountsEmotional developmentRecent imaging studiesSelf-RegulationSocial situationsNeural circuitryYoung adulthoodAdolescenceImaging studiesHierarchical changesCircuitryDynamic reorganizationSubcorticoBrainCascade of changesAdulthoodLimbicControl circuitrySituationInstantiationDevelopment
2016
Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study
Gabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional connectivityAmygdala-medial prefrontal cortex circuitInferior frontal gyrusResting-state functional networksFunctional architectureResting-state connectivityAmygdala functional connectivityFunctional network architecturePrefrontal cortex circuitAmygdala-mPFC circuitResting-state networksFunctional connectionsEmotional stimuliCourse of developmentFrontal gyrusAge-related changesPrefrontal cortexMotivate future investigationsCortex circuitPredictive associationsSensitive periodFunctional networksDevelopmental periodBrain functionIndividual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Gee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ, Jernigan T, San Diego U, McCabe C, San Diego U, Chang L, Hawaii U, Akshoomoff N, San Diego U, Newman E, San Diego U, Dale A, San Diego U, Core M, Ernst T, Hawaii U, Dale A, San Diego U, Van Zijl P, Kuperman J, San Diego U, Murray S, Bloss C, Schork N, Appelbaum M, San Diego U, Gamst A, San Diego U, Thompson W, San Diego U, Bartsch H, San Diego U, Jernigan T, Dale A, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey B, Ruberry E, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, University Y, Gruen J. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4500-4505. PMID: 27001846, PMCID: PMC4843434, DOI: 10.1073/pnas.1600013113.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolaseAnxiety-related behaviorGene expressionFrontolimbic circuitryEndocannabinoid signalingAnxiety disordersNeural circuit maturationPostnatal day 45Phenotypic differencesFrontoamygdala circuitryAnandamide levelsGenetic effectsAEA levelsBiological stateIndividual differencesCircuit maturationGenetic alterationsFAAH genotypeMouse modelDevelopmental neurobiologyLevels of analysisAdolescent changesDevelopmental windowAmide hydrolaseBrain circuitry
2015
Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study
Gee DG, McEwen SC, Forsyth JK, Haut KM, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet D, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TG, Walker EF, Hamann S, Woods SW, Constable T, Cannon TD. Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study. Human Brain Mapping 2015, 36: 2558-2579. PMID: 25821147, PMCID: PMC4478164, DOI: 10.1002/hbm.22791.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging (fMRI) taskBlood oxygen level-dependent (BOLD) signalFusiform gyrusRobust activationEmotion processing areasAnterior cingulate cortexLevel-dependent signalBrain-related changesMean activationExcellent reliabilityPatient groupRare conditionInferior frontal gyrusHealthy volunteersGeneral populationEmotion processing taskHealthy individualsCingulate cortexMultisite longitudinal studyConsecutive daysFrontal gyrusAmygdalaBrain activationMultisite studyMixed effects models