2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2020
Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortex
2019
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
Meyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26970-26979. PMID: 31822612, PMCID: PMC6936350, DOI: 10.1073/pnas.1910481116.Peer-Reviewed Original ResearchCompound cueAnxiety disordersPrelimbic cortexSafety signal learningCurrent evidence-based treatmentsVentromedial prefrontal cortexCognitive behavioral therapyAlternative neural mechanismVentral hippocampal neuronsPresence of threatNeural activity patternsEvidence-based treatmentsAnxious individualsThreat cuesEvidence-based interventionsSafety learningFear extinctionVentral hippocampusThreat responsesSignal learningNeural mechanismsBehavioral therapyInhibition paradigmPrefrontal cortexHippocampal responses
2017
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.Peer-Reviewed Original ResearchConceptsAnxiety-related behaviorDevelopmental trajectoriesAdolescent brain developmentRegulation of fearConsequences of stressGenetic variationBrain developmentBehavioral processingECB systemPrefrontal cortexEmotional behaviorHuman genetic variationCorticolimbic structuresStress responsivityBrain regionsAdolescenceRegulation of stressNeural circuitsEndocannabinoid systemAnxietyEnvironmental perturbationsRole of eCBFunctional implicationsCentral roleLife span
2016
Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study
Gabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional connectivityAmygdala-medial prefrontal cortex circuitInferior frontal gyrusResting-state functional networksFunctional architectureResting-state connectivityAmygdala functional connectivityFunctional network architecturePrefrontal cortex circuitAmygdala-mPFC circuitResting-state networksFunctional connectionsEmotional stimuliCourse of developmentFrontal gyrusAge-related changesPrefrontal cortexMotivate future investigationsCortex circuitPredictive associationsSensitive periodFunctional networksDevelopmental periodBrain function
2011
Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study
Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD, Consortium O. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study. Schizophrenia Research 2011, 134: 1-9. PMID: 22056201, PMCID: PMC3245800, DOI: 10.1016/j.schres.2011.10.005.Peer-Reviewed Original ResearchConceptsClinical high riskFunctional connectivityPrefrontal cortexCHR adolescentsHigh riskAmygdala-prefrontal functional connectivityAmygdala-prefrontal circuitryCross-sectional analysisPsychophysiological interaction analysisVLPFC activationIllness onsetAge-related trajectoriesRisk syndromeVentrolateral prefrontal cortexInteraction of ageOvert psychosisAge-related variationsPsychosisAmygdala reactivityBrain connectivityFunctional activationAmygdalaCortexLater deficitsFMRI task