2004
An Increased Capacity for Adrenal DHEA Release is Associated with Decreased Avoidance and Negative Mood Symptoms in Women with PTSD
Rasmusson AM, Vasek J, Lipschitz DS, Vojvoda D, Mustone ME, Shi Q, Gudmundsen G, Morgan CA, Wolfe J, Charney DS. An Increased Capacity for Adrenal DHEA Release is Associated with Decreased Avoidance and Negative Mood Symptoms in Women with PTSD. Neuropsychopharmacology 2004, 29: 1546-1557. PMID: 15199367, DOI: 10.1038/sj.npp.1300432.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderNegative mood symptomsAdrenal cortisol responsePremenopausal womenMood symptomsPTSD subjectsCortisol responseDHEA releaseAdrenal activationClinician-Administered PTSD Scale scoresChronic post-traumatic stress disorderHPA axis adaptationCorticotropin-releasing factorSeverity of PTSDEndogenous plasma levelsNontraumatized subjectsAdrenal axisDHEAS levelsPlasma levelsAdrenocorticotropic hormonePituitary ACTHProgesterone levelsDHEA responsesHealthy individualsAntiglucocorticoid mifepristone
2001
Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder
Rasmusson A, Lipschitz D, Wang S, Hu S, Vojvoda D, Bremner J, Southwick S, Charney D. Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biological Psychiatry 2001, 50: 965-977. PMID: 11750893, DOI: 10.1016/s0006-3223(01)01264-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdrenal axis regulationAdrenocorticotropic hormonePremenopausal womenPosttraumatic stress disorder subjectsPosttraumatic stress disorder groupCortisol responseStress disorderAxis regulationCortisol levelsUrinary free cortisol excretionDisorder subjectsUrinary free cortisol measurementChronic posttraumatic stress disorderDisorder groupAdrenocorticotropin stimulation testPeak cortisol responseMenstrual cycle phaseBaseline cortisol levelsGreater cortisol responseBaseline adrenocorticotropic hormoneLH surgeExogenous corticotropinPsychotropic medicationsStimulation test