2012
Neuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity‐based computerized cognitive remediation for geriatric depression. International Journal Of Geriatric Psychiatry 2012, 27: 1239-1247. PMID: 22451346, PMCID: PMC3387346, DOI: 10.1002/gps.3776.Peer-Reviewed Original ResearchConceptsComputerized cognitive remediationCognitive remediationExecutive dysfunctionGeriatric depressionSpecific executive deficitsSpecific neurocognitive deficitsSpecific cerebral networksNovel treatment interventionsAvailable treatment studiesNovel treatment modelExecutive deficitsEmotional regulationNeurocognitive deficitsUnderlying neurobiologyMental health reportsCerebral networksOlder adultsTreatment modelTreatment interventionsDepressed eldersTreatment studiesBehavioral changesNew interventionsDepressionDeficits
2002
Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces
Bruder GE, Stewart JW, McGrath PJ, Julie G, Wexler BE, Quitkin FM. Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces. Journal Of Psychopathology And Clinical Science 2002, 111: 446-454. PMID: 12150420, DOI: 10.1037/0021-843x.111.3.446.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAtypical depressionTypical depressionRight hemispheric dominanceNeurophysiologic studiesDepressive disorderHealthy controlsVegetative symptomsPatientsDistinct subtypesDiagnostic distinctionHemisphere biasHemispheric dominanceDepressionDysthymiaRight hemisphere biasFurther evidenceFace testHemispatial biasPhysical anhedoniaSymptomsSubtypesControl
1999
Perceptual Asymmetry Differences Between Major Depression With or Without a Comorbid Anxiety Disorder: A Dichotic Listening Study
Bruder G, Wexler B, Stewart J, Price L, Quitkin F. Perceptual Asymmetry Differences Between Major Depression With or Without a Comorbid Anxiety Disorder: A Dichotic Listening Study. Journal Of Psychopathology And Clinical Science 1999, 108: 233-239. PMID: 10369033, DOI: 10.1037/0021-843x.108.2.233.Peer-Reviewed Original ResearchConceptsPerceptual asymmetryEmotional wordsLarge left ear advantageSmaller right-ear advantageLeft-hemisphere regionsDichotic listening taskNonanxious depressionDichotic listening studyLeft ear advantageRight ear advantageComorbid anxiety disordersOpposite hemispheric asymmetryAuditory taskTone taskAnxious groupListening taskNonanxious groupsAnxiety disordersHemispheric asymmetryGroup differencesTaskWordsDepression groupAsymmetry differencesMajor depressive disorder
1994
Decreased perceptual sensitivity to emotion-evoking stimuli in depression
Wexler B, Levenson L, Warrenburg S, Price L. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research 1994, 51: 127-138. PMID: 8022947, DOI: 10.1016/0165-1781(94)90032-9.Peer-Reviewed Original ResearchConceptsFacial displaysOwn faceNegative emotion-related wordsEmotion-evoking stimuliEmotion-related wordsDichotic listening paradigmEmotion-related stimuliNegative facial displaysNormal cognitive processingNeutral wordsAutomatic mimicryCognitive processingPerceptual sensitivityFacial mimicryNegative wordsEmotional responsesDichotic testsSelective perceptionDepressed patientsStimuliWordsHealthy controlsEmotionsFaceSuch measures
1992
The Outpatient Treatment of Depression
WEXLER B, CICCHETTI D. The Outpatient Treatment of Depression. The Journal Of Nervous And Mental Disease 1992, 180: 277-286. PMID: 1533868, DOI: 10.1097/00005053-199205000-00001.Peer-Reviewed Original ResearchConceptsTreatment failure rateTreatment success rateTreatment dropout ratesInitial treatmentRoutine treatmentOutpatient treatmentEffective treatmentDepressed outpatientsSide effectsClinical practiceCombined treatmentRoutine useIndividual psychotherapyMultiple studiesSuccess rateTreatmentPharmacotherapyModest advantageFailure rateDropout ratePsychotherapyUnnecessary costsPatientsOutpatients
1991
Cerebral laterality, symptoms, and diagnosis in psychotic patients
Wexler B, Giller E, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry 1991, 29: 103-116. PMID: 1995082, DOI: 10.1016/0006-3223(91)90039-o.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrainDepressive DisorderDichotic Listening TestsFunctional LateralityHumansMaleMiddle AgedProhibitinsPsychotic DisordersSchizophreniaConceptsRight ear advantageLower right-ear advantagesManic patientsPositive symptomsNegative symptomsCerebral lateralitySubset of patientsDisease-related decreaseWord TestSchizoaffective patientsSymptomatic inpatientsDepressed patientsHealthy controlsSymptom remissionSchizophrenic patientsMood disturbancePatientsMore symptomsPsychotic patientsSymptomsDichotic word testLeft hemisphereEar advantageThought disorderSimilar changes
1989
Possible Subtypes of Affective Disorder Suggested by Differences in Cerebral Laterality and Testosterone: A Preliminary Report
Wexler B, Mason J, Giller E. Possible Subtypes of Affective Disorder Suggested by Differences in Cerebral Laterality and Testosterone: A Preliminary Report. JAMA Psychiatry 1989, 46: 429-433. PMID: 2712661, DOI: 10.1001/archpsyc.1989.01810050043007.Peer-Reviewed Original ResearchConceptsSerum testosterone levelsDichotic listening testAffective disordersTestosterone levelsMean serum testosterone levelCerebral lateralityTime of admissionPathophysiological heterogeneityDiagnostic groupsSymptom severityPreliminary reportPossible subtypesHemisphere functionDisordersSubgroupsLateralityMeaningful subgroupsPositive correlationNegative correlationGroupHospitalizationPatientsAdmissionPathogenesesTestosterone