Bruce E Wexler, MD
Professor Emeritus of PsychiatryCards
About
Titles
Professor Emeritus of Psychiatry
Biography
Digital Neurotherapy: Helped launch the field with studies published in 1997, 2000.
Brain and Culture (MIT Press 2006) seminal text in cultural neuroscience (new edition forthcoming).
NIH Director's Award for high impact, high innovation, paradigm changing medical research, supporting development of digital neurotherapy 2012-2016.
Founder and President "A Different Future", an NGO to reclaim the public idea space from extremists regarding the Israeli-Palestinian conflict 2002-14 (co-founders Ambassador Andrew Young and Rabbi Alvin Sugarman); Facilitator for the Council of Religious Institutions of the Holy Land, conducted U.S. State Department funded study of how "the other" is portrayed in Israeli and Palestinian school books 2007-13 (convener Rev Trond Bakkevig) .
Founder and Chief Scientist, C8 Sciences 2011- present, harnessing neuroplasticity in technology-enhanced content-independent micro-cognition training and assessment programs to directly improve thinking abilities and close academic achievement gaps in 5-9 year old children, provide scalable, non-invasive micro-cognition biomarkers to transform psychiatric diagnosis and create novel digital neurotherapies that improve outcomes in ADHD, Depression, Schizophrenia and Mild Cognitive Impairment.
Founder and Chief Scientist, Neutargeton Therapeutics 2023- present, non-invasive digital activation of nano-carrier technology to deliver CNS drugs to where they are needed in the brain and increase on-target treatment effects and decrease off-target side effects. Patent approved in <85 days because of absence of any prior art
Appointments
Psychiatry
EmeritusPrimary
Other Departments & Organizations
Education & Training
- MD
- Albert Einstein College of Medicine (1973)
- BA
- Harvard College, Government (1969)
Research
Publications
2025
Brain-wide connectivity changes due to social–emotional regulation during a naturalistic fMRI task
Hyatt C, Wexler B, Diefenbach G, Dichter G, Mazefsky C, Uscatescu L, Wolf J, Sahl R, Pittman B, Pearlson G, Assaf M. Brain-wide connectivity changes due to social–emotional regulation during a naturalistic fMRI task. Cerebral Cortex 2025, 35: bhaf118. PMID: 40401354, PMCID: PMC12096004, DOI: 10.1093/cercor/bhaf118.Peer-Reviewed Original Research
2024
Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original Research
2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchUsing micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function
Wexler B, Kish R. Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function. Psychiatry Research 2023, 326: 115348. PMID: 37494880, PMCID: PMC10517859, DOI: 10.1016/j.psychres.2023.115348.Peer-Reviewed Original ResearchAberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia
Peterson B, Kaur T, Sawardekar S, Colibazzi T, Hao X, Wexler B, Bansal R. Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia. Frontiers In Cellular Neuroscience 2023, 17: 1126577. PMID: 36909281, PMCID: PMC9996667, DOI: 10.3389/fncel.2023.1126577.Peer-Reviewed Original Research
2022
Returning to basic principles to develop more effective treatments for central nervous system disorders
Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology And Medicine 2022, 247: 856-867. PMID: 35172621, PMCID: PMC9158240, DOI: 10.1177/15353702221078291.Peer-Reviewed Original Research
2021
The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial
Westwood SJ, Bozhilova N, Criaud M, Lam SL, Lukito S, Wallace-Hanlon S, Kowalczyk OS, Kostara A, Mathew J, Wexler BE, Kadosh RC, Asherson P, Rubia K. The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial. IBRO Neuroscience Reports 2021, 12: 55-64. PMID: 35746969, PMCID: PMC9210460, DOI: 10.1016/j.ibneur.2021.12.005.Peer-Reviewed Original ResearchAtypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism
Hyatt CJ, Wexler BE, Pittman B, Nicholson A, Pearlson GD, Corbera S, Bell MD, Pelphrey K, Calhoun VD, Assaf M. Atypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism. Cerebral Cortex 2021, 32: 3406-3422. PMID: 34875687, PMCID: PMC9376868, DOI: 10.1093/cercor/bhab423.Peer-Reviewed Original ResearchPredictors of social functioning and quality of life in schizophrenia and autism spectrum disorder
Corbera S, Wexler BE, Bell MD, Pearlson G, Mayer S, Pittman B, Belamkar V, Assaf M. Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder. Psychiatry Research 2021, 303: 114087. PMID: 34246005, PMCID: PMC8373814, DOI: 10.1016/j.psychres.2021.114087.Peer-Reviewed Original ResearchOpinion Mental Health: Digital Neuroscience can help alleviate the mental health crisis.
Wexler B. Opinion Mental Health: Digital Neuroscience can help alleviate the mental health crisis. Financial Times April 23, 2021.Commentaries, Editorials and Letters
Clinical Trials
Current Trials
Sleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
IRB ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements & Community Involvement
Get In Touch
Contacts
Psychiatry
95 rogers rd
hamden, Connecticut 06517
United States
Locations
Koerner Center
Academic Office
149 Elm Street, Fl 2nd
New Haven, CT 06511