2016
Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2003
Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study
Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK, Rounsaville BJ, Gore JC, Wexler BE. Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study. JAMA Psychiatry 2003, 60: 828-836. PMID: 12912766, DOI: 10.1001/archpsyc.60.8.828.Peer-Reviewed Original ResearchConceptsPathological gamblingGambling urgesBrain activityEchoplanar functional magnetic resonance imagingPG subjectsFunctional magnetic resonance imaging studyGroup differencesFunctional magnetic resonance imagingVentral anterior cingulateRegional brain activityBrain activity changesGambling cuesMagnetic resonance imaging studyResonance imaging studyNeural correlatesMotivational responsesBrain mechanismsGambling stimuliImpulse regulationTemporal epochsSad contentGambling behaviorOrbitofrontal cortexLimbic brain structuresAnterior cingulate
1995
Abnormal laterality in schizophrenics and their parents
Grosh E, Docherty N, Wexler B. Abnormal laterality in schizophrenics and their parents. Schizophrenia Research 1995, 14: 155-160. PMID: 7710996, DOI: 10.1016/0920-9964(94)00033-5.Peer-Reviewed Original ResearchConceptsRight ear advantageNegative emotional valenceEmotional valenceHemispheric activationLower right-ear advantagesPositive emotional valenceLateralized cerebral functionsLeft-hemispheric activationDichotic word testNeutral wordsPerceptual asymmetryPerceptual advantageWord TestDichotic testsEar advantageValenceWordsParentsAbnormal lateralitySchizophrenic offspringSchizophrenicsSchizophrenic patientsCerebral functionSame subjectsLaterality
1994
Abnormalities in rapid, automatic aspects of attention in schizophrenia: blunted inhibition of return
Huey E, Wexler B. Abnormalities in rapid, automatic aspects of attention in schizophrenia: blunted inhibition of return. Schizophrenia Research 1994, 14: 57-63. PMID: 7893622, DOI: 10.1016/0920-9964(94)90009-4.Peer-Reviewed Original ResearchConceptsHealthy subjectsHealthy control subjectsStable schizophrenic outpatientsInhibition of returnMs intervalsControl subjectsSchizophrenic outpatientsNormal intervalsInhibitory mechanismInhibitionVisual stimuliSchizophrenicsSubjectsStimuliIntervalPresent experimentsOutpatientsAbnormalitiesSchizophreniaDecreased perceptual sensitivity to emotion-evoking stimuli in depression
Wexler B, Levenson L, Warrenburg S, Price L. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research 1994, 51: 127-138. PMID: 8022947, DOI: 10.1016/0165-1781(94)90032-9.Peer-Reviewed Original ResearchConceptsFacial displaysOwn faceNegative emotion-related wordsEmotion-evoking stimuliEmotion-related wordsDichotic listening paradigmEmotion-related stimuliNegative facial displaysNormal cognitive processingNeutral wordsAutomatic mimicryCognitive processingPerceptual sensitivityFacial mimicryNegative wordsEmotional responsesDichotic testsSelective perceptionDepressed patientsStimuliWordsHealthy controlsEmotionsFaceSuch measuresNeuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic
Sernyak M, Griffin R, Johnson R, Pearsall H, Wexler B, Woods S. Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic. American Journal Of Psychiatry 1994, 151: 133-135. PMID: 7903511, DOI: 10.1176/ajp.151.1.133.Peer-Reviewed Original Research
1991
Cerebral laterality, symptoms, and diagnosis in psychotic patients
Wexler B, Giller E, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry 1991, 29: 103-116. PMID: 1995082, DOI: 10.1016/0006-3223(91)90039-o.Peer-Reviewed Original ResearchConceptsRight ear advantageLower right-ear advantagesManic patientsPositive symptomsNegative symptomsCerebral lateralitySubset of patientsDisease-related decreaseWord TestSchizoaffective patientsSymptomatic inpatientsDepressed patientsHealthy controlsSymptom remissionSchizophrenic patientsMood disturbancePatientsMore symptomsPsychotic patientsSymptomsDichotic word testLeft hemisphereEar advantageThought disorderSimilar changes
1983
Increasing the power of dichotic methods: The fused rhymed words test
Wexler B, Halwes T. Increasing the power of dichotic methods: The fused rhymed words test. Neuropsychologia 1983, 21: 59-66. PMID: 6843817, DOI: 10.1016/0028-3932(83)90100-8.Peer-Reviewed Original Research