2019
Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification
Rabany L, Brocke S, Calhoun VD, Pittman B, Corbera S, Wexler BE, Bell MD, Pelphrey K, Pearlson GD, Assaf M. Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification. NeuroImage Clinical 2019, 24: 101966. PMID: 31401405, PMCID: PMC6700449, DOI: 10.1016/j.nicl.2019.101966.Peer-Reviewed Original Research
2018
Measuring theory of mind in schizophrenia research: Cross-cultural validation
Lee HS, Corbera S, Poltorak A, Park K, Assaf M, Bell MD, Wexler BE, Cho YI, Jung S, Brocke S, Choi KH. Measuring theory of mind in schizophrenia research: Cross-cultural validation. Schizophrenia Research 2018, 201: 187-195. PMID: 29958750, DOI: 10.1016/j.schres.2018.06.022.Peer-Reviewed Original ResearchConceptsSocial Attribution Task-Multiple ChoiceTheory of mindSocial cognition measuresSocial cognition tasksSocial cognitive impairmentsSchizophrenia researchInternal consistencyConvergent/divergent validityConfirmatory factor analysisGood internal consistencyOne-factor modelCognition measuresCognition tasksIndividual differencesGood model fitCross-cultural validationMental statesMeasurement invarianceDivergent validityDiscriminant validityToMFactor structureHealthy controlsCognitive impairmentDiverse languages
2016
Cognitive remediation for adults with schizophrenia: Does age matter?
Corbera S, Wexler BE, Poltorak A, Thime WR, Kurtz MM. Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research 2016, 247: 21-27. PMID: 27863314, PMCID: PMC5248553, DOI: 10.1016/j.psychres.2016.10.084.Peer-Reviewed Original ResearchConceptsCognitive remediationSubstantial individual differencesEarly chronic groupsOlder client populationNovel behavioral interventionSubsample of clientsRole of ageMemory measuresIndividual differencesStrategy acquisitionCognitive outcomesCognitive deficitsTask practiceRandomized control trialBehavioral interventionsTrend levelEmpirical supportSchizophreniaTreatment responseAge matterClient populationEarly-stage groupAge rangeGreater improvementAdults
2015
Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
Kober H, Lacadie CM, Wexler BE, Malison RT, Sinha R, Potenza MN. Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study. Neuropsychopharmacology 2015, 41: 628-637. PMID: 26119472, PMCID: PMC5130138, DOI: 10.1038/npp.2015.193.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCD participantsCocaine dependenceCocaine cravingPG participantsPathological gamblingGender-specific therapiesBrain activityMagnetic resonance imagingNeural correlatesSelf-reported cravingInsula/Ventromedial prefrontal cortexNeurobiological similaritiesResonance imagingGambling urgesDrug cravingPrefrontal cortexDorsal mPFCControl participantsCravingFMRI studyMPFC regionFuture studiesParticipantsSocial skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2014
Physiological evidence of a deficit to enhance the empathic response in schizophrenia
Corbera S, Ikezawa S, Bell MD, Wexler BE. Physiological evidence of a deficit to enhance the empathic response in schizophrenia. European Psychiatry 2014, 29: 463-472. PMID: 24630376, DOI: 10.1016/j.eurpsy.2014.01.005.Peer-Reviewed Original ResearchConceptsEvent-related potentialsEmpathic responsesERP responsesPersonal distressRegulatory deficitsLate cognitive componentsSocial cognition processesPictures of handsEffective social interactionsLate ERP responsesOwn emotional engagementCognitive empathyTask demandsPerspective takingCognition processEmpathic conditionEmotional engagementSocial situationsSocial interactionEmpathyPainful situationsSubjective ratingsOwn painPain paradigmDistressIncreasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuliNeural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrusBenefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning
Bell MD, Choi KH, Dyer C, Wexler BE. Benefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning. Psychiatric Services 2014, 65: 469-475. PMID: 24382594, DOI: 10.1176/appi.ps.201200505.Peer-Reviewed Original Research
2013
Emotion self-regulation and empathy depend upon longer stimulus exposure
Ikezawa S, Corbera S, Wexler BE. Emotion self-regulation and empathy depend upon longer stimulus exposure. Social Cognitive And Affective Neuroscience 2013, 9: 1561-1568. PMID: 24064924, PMCID: PMC4187273, DOI: 10.1093/scan/nst148.Peer-Reviewed Original ResearchConceptsLate positive potentialSelf-regulatory processesEvent-related potentialsEmpathic responsesLate event-related potentialsThreat-related stimuliPain-related stimuliLonger stimulus exposuresLate ERP componentsPictures of handsStimulus exposure durationAttentional modulationERP responsesERP componentsNeural basisBrain processingStimulus exposureTask conditionsStimulus presentationNeutral situationsProcessing existClinical populationsStimulus durationExposure durationJudgment conditionAnatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsA pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia
Surti TS, Wexler BE. A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophrenia Research 2012, 142: 248-249. PMID: 23043873, DOI: 10.1016/j.schres.2012.09.013.Peer-Reviewed Original ResearchDoes baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areasComputerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2011
Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates?
Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates? Schizophrenia Bulletin 2011, 39: 186-196. PMID: 21976710, PMCID: PMC3523908, DOI: 10.1093/schbul/sbr125.Peer-Reviewed Original ResearchConceptsHigher social cognitionLower social cognitionSocial cognitive impairmentsHigh-negative symptom groupSocial cognitionNegative-symptom groupNegative symptomsCaruso Emotional Intelligence TestSocial cognitive measuresEmotional Intelligence TestSocial cognitive factorsCognitive impairmentSymptom groupsNegative symptom factorMayer-SaloveyCommon assessment instrumentsCognitive factorsCognitive measuresSubstance abuse historyIntelligence testsCore featuresAbuse historyIndependent dimensionsDistinct factorsSymptom factorsSuccessful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipants
2010
Predictors of Participation in Community Outpatient Psychosocial Rehabilitation in Schizophrenia
Kurtz MM, Rose J, Wexler BE. Predictors of Participation in Community Outpatient Psychosocial Rehabilitation in Schizophrenia. Community Mental Health Journal 2010, 47: 622-627. PMID: 20676766, PMCID: PMC3046324, DOI: 10.1007/s10597-010-9343-z.Peer-Reviewed Original ResearchConceptsLower verbal fluency scoresVerbal fluency scoresSchizoaffective disorderPsychosocial rehabilitation programsVerbal learningVerbal abilityNeurocognitive factorsVisual vigilanceVerbal fluencyFluency scoresNeurocognitive assessmentDSM-IV schizophreniaSymptom measuresPsychosocial rehabilitationPredictors of participationDemographic variablesSchizophreniaFinal multivariate modelRehabilitation programGreater likelihoodRace/ethnicityStudy entryFluencyDisordersMeasuresSocial attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures
Bell MD, Fiszdon JM, Greig TC, Wexler BE. Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures. Schizophrenia Research 2010, 122: 164-171. PMID: 20400268, PMCID: PMC2908733, DOI: 10.1016/j.schres.2010.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceChoice BehaviorCognition DisordersDisability EvaluationFemaleHumansInterpersonal RelationsLogistic ModelsMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesReproducibility of ResultsResidence CharacteristicsROC CurveSchizophreniaSchizophrenic PsychologySocial PerceptionConceptsSocial Attribution Task-Multiple ChoiceSocial cognitive measuresCognitive measuresAffect recognitionCommunity sampleSocial cognitive impairmentsTheory of mindSignificant group differencesMATRICS batteryNeurocognitive measuresSCZ participantsVerbal processesAutism researchCognition indexLongitudinal designSymptom measuresGroup differencesCognitive impairmentCommunity-dwelling participantsGeometric figuresSchizoaffective disorderParticipantsSchizophreniaImpairmentMultiple-choice questionsMemory profiles in schizophrenia: Categorization validity and stability
Bell MD, Johannesen JK, Greig TC, Wexler BE. Memory profiles in schizophrenia: Categorization validity and stability. Schizophrenia Research 2010, 118: 26-33. PMID: 20085855, PMCID: PMC3699867, DOI: 10.1016/j.schres.2009.12.037.Peer-Reviewed Original ResearchConceptsSocial cognitive domainsMemory profileCognitive domainsHopkins Verbal LearningCluster analytic techniquesSocial cognitionVerbal learningVerbal memorySubcortical impairmentNeuropsychological assessmentCommunity mental health centerCortical impairmentMental health centersSchizoaffective disorderMotor speedCurrent studySchizophreniaIllness characteristicsMemoryUrban community mental health centerImpairmentSimple decision rulesCognitionCluster analysisCluster groups