2021
Atypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism
Hyatt CJ, Wexler BE, Pittman B, Nicholson A, Pearlson GD, Corbera S, Bell MD, Pelphrey K, Calhoun VD, Assaf M. Atypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism. Cerebral Cortex 2021, 32: 3406-3422. PMID: 34875687, PMCID: PMC9376868, DOI: 10.1093/cercor/bhab423.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial-emotional processingDFNC statesDifferent neural processingFunction of emotionFunctional connectivity patternsHappy videosSad videosNeutral contentNeural processingTask scoresSpectrum disorderDifferential engagementDFNC measuresMore timeYoung adultsConnectivity patternsState engagementEmotionsSchizophreniaIndependent component analysisEngagementProcessingSignificant relationshipAlexithymia
2019
Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification
Rabany L, Brocke S, Calhoun VD, Pittman B, Corbera S, Wexler BE, Bell MD, Pelphrey K, Pearlson GD, Assaf M. Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification. NeuroImage Clinical 2019, 24: 101966. PMID: 31401405, PMCID: PMC6700449, DOI: 10.1016/j.nicl.2019.101966.Peer-Reviewed Original Research
2015
Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
Kober H, Lacadie CM, Wexler BE, Malison RT, Sinha R, Potenza MN. Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study. Neuropsychopharmacology 2015, 41: 628-637. PMID: 26119472, PMCID: PMC5130138, DOI: 10.1038/npp.2015.193.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCD participantsCocaine dependenceCocaine cravingPG participantsPathological gamblingGender-specific therapiesBrain activityMagnetic resonance imagingNeural correlatesSelf-reported cravingInsula/Ventromedial prefrontal cortexNeurobiological similaritiesResonance imagingGambling urgesDrug cravingPrefrontal cortexDorsal mPFCControl participantsCravingFMRI studyMPFC regionFuture studiesParticipants
2012
Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2005
Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE. Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology 2005, 183: 171-180. PMID: 16163517, DOI: 10.1007/s00213-005-0147-8.Peer-Reviewed Original ResearchConceptsStress-induced cocaineCocaine-dependent individualsFunctional magnetic resonance imaging sessionNeural activityFunctional magnetic resonance imaging studyMagnetic resonance imaging sessionCocaine cravingRegulation of emotionHippocampal/parahippocampal regionLevel-dependent signal changesRight fusiform gyrusStress-related vulnerabilityPara-limbic regionsAnterior cingulate regionsRight postcentral gyrusDependent signal changesMagnetic resonance imaging studyResonance imaging studyStress processingFusiform gyrusNeutral situationsSpecific frontalBOLD activationPersonal stressCingulate regions
2004
Neural Circuits Underlying Emotional Distress in Humans
SINHA R, LACADIE C, SKUDLARSKI P, WEXLER BE. Neural Circuits Underlying Emotional Distress in Humans. Annals Of The New York Academy Of Sciences 2004, 1032: 254-257. PMID: 15677422, DOI: 10.1196/annals.1314.032.Peer-Reviewed Original ResearchConceptsEmotional distressHealthy volunteersFunctional magnetic resonance imaging (fMRI) techniquesStressful life eventsEmotional stressPosterior cingulate regionsPrefrontal cortical circuitsSubstance use disordersStress processingBrain activationBrain correlatesImagery trialsMedial prefrontalAnterior cingulateLife eventsCingulate regionsMagnetic resonance imaging techniquesParahippocampal gyrusCortical circuitsUse disordersHealthy individualsDistressNeural circuitsSignificant activationClinical samples
2003
Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study
Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK, Rounsaville BJ, Gore JC, Wexler BE. Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study. JAMA Psychiatry 2003, 60: 828-836. PMID: 12912766, DOI: 10.1001/archpsyc.60.8.828.Peer-Reviewed Original ResearchConceptsPathological gamblingGambling urgesBrain activityEchoplanar functional magnetic resonance imagingPG subjectsFunctional magnetic resonance imaging studyGroup differencesFunctional magnetic resonance imagingVentral anterior cingulateRegional brain activityBrain activity changesGambling cuesMagnetic resonance imaging studyResonance imaging studyNeural correlatesMotivational responsesBrain mechanismsGambling stimuliImpulse regulationTemporal epochsSad contentGambling behaviorOrbitofrontal cortexLimbic brain structuresAnterior cingulate
2001
Functional MR imaging of regional brain activation associated with the affective experience of pain.
Fulbright R, Troche C, Skudlarski P, Gore J, Wexler B. Functional MR imaging of regional brain activation associated with the affective experience of pain. American Journal Of Roentgenology 2001, 177: 1205-10. PMID: 11641204, DOI: 10.2214/ajr.177.5.1771205.Peer-Reviewed Original ResearchConceptsAnterior cingulate gyrusSuperior frontal gyrusCingulate gyrusPain taskRight cuneusFunctional MRFrontal gyrusRight superior frontal gyrusBrain activationPain-related activationCold pressor testLeft anterior insulaExperience of painRegional brain activationFunctional MR imagingMotor-sensory areasPainful temperaturesPain thresholdLeft thalamusPressor testPainful levelsPostcentral gyrusPainFrontal lobeHealthy adults
1998
Functional MR imaging of regional brain responses to pleasant and unpleasant odors.
Fulbright RK, Skudlarski P, Lacadie CM, Warrenburg S, Bowers AA, Gore JC, Wexler BE. Functional MR imaging of regional brain responses to pleasant and unpleasant odors. American Journal Of Neuroradiology 1998, 19: 1721-6. PMID: 9802496, PMCID: PMC8337499.Peer-Reviewed Original ResearchConceptsFunctional MR imagingArea 8BA 6MR imagingBrodmann area 8Human cerebral cortexRegional brain responsesMedial temporal lobeTemporal brain regionsLeft BA 6Independent t-testCerebral cortexTemporal lobeBA 32Cortical areasLeft insulaAnterior temporal brain regionsBrain regionsOrbitofrontal cortexNormal adultsIsovaleric acidOlfactory networkMore activityAir trialsBrain responses
1997
Functional Magnetic Resonance Imaging Assessment of the Human Brain Auditory Cortex Response to Increasing Word Presentation Rates
Dhankhar A, Wexler B, Fulbright R, Halwes T, Blamire A, Shulman R. Functional Magnetic Resonance Imaging Assessment of the Human Brain Auditory Cortex Response to Increasing Word Presentation Rates. Journal Of Neurophysiology 1997, 77: 476-483. PMID: 9120588, DOI: 10.1152/jn.1997.77.1.476.Peer-Reviewed Original ResearchConceptsSecondary auditory cortexAuditory cortex responsesTransverse temporal gyrusFunctional magnetic resonance imagingAuditory cortexSuperior temporal gyrusCortex responsesFunctional magnetic resonance imaging (fMRI) assessmentsMagnetic Resonance Imaging AssessmentTemporal gyrusPosterior-superior aspectEcho-planar functional magnetic resonance imagingMagnetic resonance imagingImaging assessmentGray matterResonance imagingSuperior aspectCortexSignificant differencesTemporal sulcusSubsequent fallGyrusT2 weightingImaging sequenceSubjects
1981
Right ear bias in the perception of loudness of pure tones
Wexler B, Halwes T. Right ear bias in the perception of loudness of pure tones. Neuropsychologia 1981, 19: 147-150. PMID: 7231660, DOI: 10.1016/0028-3932(81)90055-5.Peer-Reviewed Original Research