2020
An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder
Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz H, Dong J, Leckman JF. An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine 2020, 51: 1524-1535. PMID: 32090720, DOI: 10.1017/s0033291720000288.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderExperimental medicine approachTAU groupMedicine approachHyperactivity disorderWeeks of treatmentCombined subtypeDiagnosis of ADHDClinical trial designHyperactive-impulsive subtypeAttention-deficit/hyperactivity disorderCross-over designDeficit hyperactivity disorderClinical improvementClinical symptomsRandomized crossCognitive dysfunctionCT groupPathophysiological heterogeneityCONSORT recommendationsTrial designResponse rateChange scoresSubtypesTargeted pathology
2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2015
Social skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipantsBenefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning
Bell MD, Choi KH, Dyer C, Wexler BE. Benefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning. Psychiatric Services 2014, 65: 469-475. PMID: 24382594, DOI: 10.1176/appi.ps.201200505.Peer-Reviewed Original Research
2012
Neuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity‐based computerized cognitive remediation for geriatric depression. International Journal Of Geriatric Psychiatry 2012, 27: 1239-1247. PMID: 22451346, PMCID: PMC3387346, DOI: 10.1002/gps.3776.Peer-Reviewed Original ResearchMeSH KeywordsCognition DisordersCognitive Behavioral TherapyDepressive DisorderExecutive FunctionGeriatric PsychiatryHumansNeuronal PlasticityNeuropsychological TestsTherapy, Computer-AssistedConceptsComputerized cognitive remediationCognitive remediationExecutive dysfunctionGeriatric depressionSpecific executive deficitsSpecific neurocognitive deficitsSpecific cerebral networksNovel treatment interventionsAvailable treatment studiesNovel treatment modelExecutive deficitsEmotional regulationNeurocognitive deficitsUnderlying neurobiologyMental health reportsCerebral networksOlder adultsTreatment modelTreatment interventionsDepressed eldersTreatment studiesBehavioral changesNew interventionsDepressionDeficits
2011
Computerized Cognitive Remediation Treatment for Substance Abuse Disorders
Wexler BE. Computerized Cognitive Remediation Treatment for Substance Abuse Disorders. Biological Psychiatry 2011, 69: 197-198. PMID: 21199708, DOI: 10.1016/j.biopsych.2010.11.016.Peer-Reviewed Original ResearchClinical Trials as TopicCognitive Behavioral TherapyHumansSubstance-Related DisordersTherapy, Computer-Assisted
2008
Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up
Bell MD, Zito W, Greig T, Wexler BE. Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up. Schizophrenia Research 2008, 105: 18-29. PMID: 18715755, DOI: 10.1016/j.schres.2008.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyEmploymentEmployment, SupportedFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsOccupational TherapyPsychiatric Status Rating ScalesPsychotherapy, GroupPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyTreatment OutcomeVocational EducationConceptsNeurocognitive enhancement therapyEnhancement therapyComputer-based cognitive trainingCommunity-based vocational servicesWeekly support groupsCognitive remediationCognitive trainingExecutive functionWork outcomesRemediation programVocational outcomesCommunity mental health centerMental health centersCognitive impairmentSixth quarterVocational servicesNet trainingTherapy outcomeSupport groupsCompetitive employmentSchizophreniaRehabilitation methodsSchizoaffective patientsEmployment programsTrainingSymptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation
Kurtz MM, Wexler BE, Fujimoto M, Shagan DS, Seltzer JC. Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research 2008, 102: 303-311. PMID: 18495433, PMCID: PMC2519168, DOI: 10.1016/j.schres.2008.03.023.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAmbulatory CareCognition DisordersCognitive Behavioral TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyTherapy, Computer-AssistedVerbal LearningConceptsEveryday life skillsPerformance-based measuresLife skillsVerbal learningVerbal abilityCognitive rehabilitation interventionLongitudinal studyPredictors of changeMeasures of symptomsCognitive interventionsVisual vigilanceSustained vigilanceProcessing speedNeurocognitive deficitsNeurocognitive functionNegative symptomsBody of literatureNeurocognitionSkillsRehabilitation interventionsSchizoaffective disorderOutpatient rehabilitationCurrent studySchizophreniaRehabilitation strategies
2007
Improved cognitive function in schizophrenia after one year of cognitive training and vocational services
Greig TC, Zito W, Wexler BE, Fiszdon J, Bell MD. Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research 2007, 96: 156-161. PMID: 17669629, PMCID: PMC2080620, DOI: 10.1016/j.schres.2007.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionCognitive Behavioral TherapyEthnicityFemaleHumansMaleOutpatientsPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyConceptsNeurocognitive enhancement therapyCognitive training exercisesCognitive remediation programNeuropsychological test batterySchizoaffective disorderCognitive trainingExecutive functionEnhancement therapyTest batteryCognitive functionCognitive deficitsRemediation programVocational programsCommunity mental health centerYear-long programMental health centersFeedback groupVocational servicesStable outpatientsParticipantsSchizophreniaTraining exercisesProcessing groupUrban community mental health centerSupport programsNeurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance
2005
Cognitive Remediation and Vocational Rehabilitation for Schizophrenia
Wexler BE, Bell MD. Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin 2005, 31: 931-941. PMID: 16079390, DOI: 10.1093/schbul/sbi038.Peer-Reviewed Original ResearchMeSH KeywordsCognition DisordersCognitive Behavioral TherapyEmploymentHumansPrognosisSchizophreniaTreatment OutcomeVocational GuidanceConceptsCognitive remediation treatmentAspects of schizophreniaCognitive remediationCognitive deficitsWork functioningBehavioral interventionsWork therapyCognitionVocational rehabilitationArea of researchLasting improvementMental illnessSchizophreniaMajor mental illnessRemediation treatmentsFunctioningDeficitsInterventionMultiple studiesReadersResearchRehabilitationNeurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups
Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. Neurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups. The Journal Of Rehabilitation Research And Development 2005, 42: 829. PMID: 16680620, DOI: 10.1682/jrrd.2005.03.0061.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyCombined Modality TherapyFollow-Up StudiesHumansMiddle AgedNeuropsychological TestsOdds RatioPatient ComplianceProbabilityPsychiatric Status Rating ScalesPsychotic DisordersRehabilitation, VocationalRisk AssessmentSchizophreniaTask Performance and AnalysisTime FactorsTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive trainingEnhancement therapyComputerized cognitive trainingExecutive functionWork outcomesCommunity mental health centerDiagnosis of schizophreniaMental health centersMental hygiene clinicSchizoaffective disorderRandom effects analysisNet trainingProductivity outcomesTrainingRehabilitation programSchizophreniaMore hoursMemoryPresent studyDisordersOutcomesEffect analysisFindings
2004
Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research 2004, 125: 1-7. PMID: 14967547, DOI: 10.1016/j.psychres.2003.10.004.Peer-Reviewed Original ResearchConceptsCognitive remediation trainingSerial position taskComputerized cognitive remediationDigit span taskSpan taskRemediation trainingCognitive remediationMemory taskPosition taskComputerized cognitive remediation trainingWork therapyActive control conditionGroups of participantsSignificant group differencesComputerized trainingCognitive retrainingComputerized tasksTraining tasksCognitive improvementCognitive deficitsCompletion of trainingGroup differencesControl conditionTaskTraining
2003
Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia
Bell M, Bryson G, Wexler BE. Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia. Acta Psychiatrica Scandinavica 2003, 108: 101-109. PMID: 12823166, DOI: 10.1034/j.1600-0447.2003.00090.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyFemaleHumansMaleMemory DisordersMiddle AgedSchizophreniaSeverity of Illness IndexTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive remediationTraining effectsSocial information processingCognitive training exercisesExecutive functionMemory performanceEnhancement therapyMemory deficitsInformation processingSeverity of impairmentDuration of trainingGreater improvementSchizoaffective disorderMemoryParticipantsTraining exercisesMost participantsImpairment severitySchizophreniaTrainingDuration of effectSeverity groupsDeficits
1992
The Outpatient Treatment of Depression
WEXLER B, CICCHETTI D. The Outpatient Treatment of Depression. The Journal Of Nervous And Mental Disease 1992, 180: 277-286. PMID: 1533868, DOI: 10.1097/00005053-199205000-00001.Peer-Reviewed Original ResearchConceptsTreatment failure rateTreatment success rateTreatment dropout ratesInitial treatmentRoutine treatmentOutpatient treatmentEffective treatmentDepressed outpatientsSide effectsClinical practiceCombined treatmentRoutine useIndividual psychotherapyMultiple studiesSuccess rateTreatmentPharmacotherapyModest advantageFailure rateDropout ratePsychotherapyUnnecessary costsPatientsOutpatients