2023
Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia
Peterson B, Kaur T, Sawardekar S, Colibazzi T, Hao X, Wexler B, Bansal R. Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia. Frontiers In Cellular Neuroscience 2023, 17: 1126577. PMID: 36909281, PMCID: PMC9996667, DOI: 10.3389/fncel.2023.1126577.Peer-Reviewed Original ResearchClinical symptomsHealthy controlsAnatomical abnormalitiesMemory deficitsPathogenesis of schizophreniaSeverity of symptomsEffects of schizophreniaHippocampal bodyAmygdala morphologyLimbic regionsPatientsHippocampusInward deformationCognitive deficitsBrain structuresHC participantsSchizophreniaAmygdalaSymptomsMemory performanceContinuum of severityAnatomical MRIPrimary disturbanceMemory scoresAbnormalities
2016
Cognitive remediation for adults with schizophrenia: Does age matter?
Corbera S, Wexler BE, Poltorak A, Thime WR, Kurtz MM. Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research 2016, 247: 21-27. PMID: 27863314, PMCID: PMC5248553, DOI: 10.1016/j.psychres.2016.10.084.Peer-Reviewed Original ResearchConceptsCognitive remediationSubstantial individual differencesEarly chronic groupsOlder client populationNovel behavioral interventionSubsample of clientsRole of ageMemory measuresIndividual differencesStrategy acquisitionCognitive outcomesCognitive deficitsTask practiceRandomized control trialBehavioral interventionsTrend levelEmpirical supportSchizophreniaTreatment responseAge matterClient populationEarly-stage groupAge rangeGreater improvementAdults
2014
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuli
2011
Heterogeneity of Auditory Verbal Working Memory in Schizophrenia
Bruder GE, Alschuler DM, Kroppmann CJ, Fekri S, Gil RB, Jarskog LF, Harkavy-Friedman JM, Goetz R, Kayser J, Wexler BE. Heterogeneity of Auditory Verbal Working Memory in Schizophrenia. Journal Of Psychopathology And Clinical Science 2011, 120: 88-97. PMID: 21319926, PMCID: PMC3061570, DOI: 10.1037/a0021661.Peer-Reviewed Original ResearchConceptsVerbal WM deficitsVerbal WMSustained attentionWM deficitsLanguage-related cortical regionsWechsler Memory Scale-RevisedAuditory hallucinationsAuditory-verbal WMVerbal Working MemoryVerbal memory deficitsGeneralized cognitive deficitHeterogeneity of schizophreniaExplicit memoryWorking memoryNonverbal memoryVisual memoryTone discriminationNonverbal testsAttentional dysfunctionAuditory perceptionSpecific deficitsCognitive deficitsMemory deficitsDiscrimination performanceMarked deficit
2008
Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia
Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, Colibazzi T, Amat J, Bansal R, Peterson BS. Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia. American Journal Of Psychiatry 2008, 166: 189-195. PMID: 18765481, PMCID: PMC4288572, DOI: 10.1176/appi.ajp.2008.08020258.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsComparison subjectsCognitive deficitsCalifornia Verbal Learning TestScores one standard deviationTests of attentionVerbal Learning TestContinuous Performance TestLarger third ventricle volumesMixed-model multivariate analysisSmaller gray matterWhite matterVentricle volumeSevere cognitive deficitsBrain structure abnormalitiesGray matterLearning TestLarger lateral ventricle volumesCognitive testsThird ventricle volumesLateral ventricle volumeWhite matter pathologySmaller white matterImpaired groupNeuropsychological testing
2007
Improved cognitive function in schizophrenia after one year of cognitive training and vocational services
Greig TC, Zito W, Wexler BE, Fiszdon J, Bell MD. Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research 2007, 96: 156-161. PMID: 17669629, PMCID: PMC2080620, DOI: 10.1016/j.schres.2007.07.003.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyCognitive training exercisesCognitive remediation programNeuropsychological test batterySchizoaffective disorderCognitive trainingExecutive functionEnhancement therapyTest batteryCognitive functionCognitive deficitsRemediation programVocational programsCommunity mental health centerYear-long programMental health centersFeedback groupVocational servicesStable outpatientsParticipantsSchizophreniaTraining exercisesProcessing groupUrban community mental health centerSupport programsNeurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance
2005
Cognitive Remediation and Vocational Rehabilitation for Schizophrenia
Wexler BE, Bell MD. Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin 2005, 31: 931-941. PMID: 16079390, DOI: 10.1093/schbul/sbi038.Peer-Reviewed Original ResearchConceptsCognitive remediation treatmentAspects of schizophreniaCognitive remediationCognitive deficitsWork functioningBehavioral interventionsWork therapyCognitionVocational rehabilitationArea of researchLasting improvementMental illnessSchizophreniaMajor mental illnessRemediation treatmentsFunctioningDeficitsInterventionMultiple studiesReadersResearchRehabilitationEffects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP. Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms. JAMA Psychiatry 2005, 62: 649-659. PMID: 15939842, DOI: 10.1001/archpsyc.62.6.649.Peer-Reviewed Original ResearchConceptsVisuospatial working memoryWorking memoryAttentional deficitsCognitive deficitsOvernight abstinenceContinuous Performance Test scoresSpatial working memoryOutpatient mental health centersPerformance test scoresCognitive enhancementCPT performanceNeuropsychological assessmentSmoking reinstatementTobacco cravingControl smokersTest scoresCounterbalanced mannerMental health centersCognitive impairmentReinstatementSubjective effectsNicotine dependenceCigarette smokingDeficitsNicotinic receptor mechanisms
2004
Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition testDurability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research 2004, 125: 1-7. PMID: 14967547, DOI: 10.1016/j.psychres.2003.10.004.Peer-Reviewed Original ResearchConceptsCognitive remediation trainingSerial position taskComputerized cognitive remediationDigit span taskSpan taskRemediation trainingCognitive remediationMemory taskPosition taskComputerized cognitive remediation trainingWork therapyActive control conditionGroups of participantsSignificant group differencesComputerized trainingCognitive retrainingComputerized tasksTraining tasksCognitive improvementCognitive deficitsCompletion of trainingGroup differencesControl conditionTaskTraining
2001
Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance
Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance. JAMA Psychiatry 2001, 58: 763-768. PMID: 11483142, DOI: 10.1001/archpsyc.58.8.763.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognitionCognition DisordersComputer-Assisted InstructionDichotic Listening TestsFeedbackFemaleFrontal LobeHumansMaleMemoryMultivariate AnalysisNeuropsychological TestsOccupational TherapyPsychomotor PerformancePsychotic DisordersSchizophreniaSchizophrenic PsychologyTeachingTreatment OutcomeConceptsNeurocognitive enhancement therapyEnhancement therapyWork therapyMental activityNeuropsychological testingLarge effect size improvementsExecutive function tasksNeuropsychological test performanceEffect size improvementsComputer-based trainingFunction tasksExecutive functionMemory performanceCognitive performanceNeuropsychological testsTraining tasksCognitive deficitsTest performanceComputer trainingCognitive dysfunctionIndependent outcome measureOccupational dysfunctionNatural contextSchizoaffective disorderMemoryEffects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia. Neuropsychopharmacology 2001, 26: 75-85. PMID: 11751034, DOI: 10.1016/s0893-133x(01)00296-2.Peer-Reviewed Original ResearchConceptsVisuospatial working memorySmoking abstinenceStroop Color-Word TestAbstinence-induced changesWorking Memory FunctionColor-Word TestPlacebo-controlled smoking cessation trialFunction of genderWorking memoryCigarette smokingWord TestSmoking cessation trialCognitive functionCognitive deficitsMemory functionNicotine-dependent cigarette smokersNon-smoking controlsSignificant impairmentPathophysiology of schizophreniaDopamine functionCortical dopamine functionCessation trialSchizophrenic smokersDepressive symptomsAbstinence
1998
Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging
Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging. JAMA Psychiatry 1998, 55: 1097-1103. PMID: 9862553, DOI: 10.1001/archpsyc.55.12.1097.Peer-Reviewed Original ResearchConceptsSerial position taskFunctional magnetic resonance imagingInferior frontal gyrusPosition taskMemory deficitsFrontal gyrusLeft inferior frontal gyrusAnterior temporal lobe areasTask-specific activationFunctional magnetic resonanceSpeech-related areasCortical hemodynamic responsesTemporal lobe areasSevere cognitive deficitsAuditory wordsWorking memoryVerbal learningNeural basisSuch deficitsCognitive deficitsCognitive functionParietal lobeLobe areasMagnetic resonance imagingCognitive dysfunction