2021
Recent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildrenAllocentric representation in the human amygdala and ventral visual stream
Evensmoen H, Rimol L, Winkler A, Betzel R, Hansen T, Nili H, Håberg A. Allocentric representation in the human amygdala and ventral visual stream. Cell Reports 2021, 34: 108658. PMID: 33472067, DOI: 10.1016/j.celrep.2020.108658.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMedial temporal lobeVentral visual streamHigh-resolution functional magnetic resonance imagingMagnetic resonance imagingBrain activation patternsDistinct neural populationsVisual streamMain brain structuresEntorhinal cortexTemporal lobePerirhinal cortexResonance imagingParahippocampal cortexBrain structuresCortexHippocampusAmygdalaFusiform cortexActivation patternsHuman amygdalaYoung menNeural populationsAllocentric representationsConnector hubs
2020
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyHumansInfantMagnetic Resonance ImagingPrefrontal CortexTemperamentConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistressInfant behavioral reactivity predicts change in amygdala volume 12 years later
Filippi C, Sachs J, Phillips D, Winkler A, Gold A, Leibenluft E, Pine D, Fox N. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Developmental Cognitive Neuroscience 2020, 42: 100776. PMID: 32452462, PMCID: PMC7096757, DOI: 10.1016/j.dcn.2020.100776.Peer-Reviewed Original ResearchConceptsYears of ageFour-month-old infantsAmygdala volumeBrain developmentAmygdala developmentPositive reactivityBehavioral reactivityStructural imagingInfant temperamentNovel evidenceChildhoodDistinct patternsCurrent studyMiddle childhoodYearsNegative reactivityReactive temperamentTemperamental reactivityInfants