Anderson M. Winkler, MD, DPhil
About
Research
Publications
2025
Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025, 61: 1397-1411. PMID: 39760730, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor networkBrain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths
Zugman A, Ringlein G, Finn E, Lewis K, Berman E, Silverman W, Lebowitz E, Pine D, Winkler A. Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths. Psychological Medicine 2025, 55: e91. PMID: 40125734, PMCID: PMC12080668, DOI: 10.1017/s0033291724003131.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyConnectome predictive modelingWeeks of cognitive-behavioral therapyCognitive behavioural therapy outcomeResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehaviour therapy outcomePediatric anxiety disordersBaseline anxiety severityBrain functional connectivityAnxiety disordersAnxiety severityPediatric anxietyAnxiety diagnosesAnxiety symptomsFunctional connectivityTherapy outcomeAnxietyFirst-line treatmentTreatment responseTreatment outcomesMagnetic resonance imagingPredictive of responseFirst-lineClinical outcomesNeural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture
Yair N, Zalmenson T, Azriel O, Shamai-Leshem D, Alon Y, Tik N, Tatsa-Laur L, Ben-Yehuda A, Pine D, Winkler A, Tavor I, Bar-Haim Y. Neural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39824285, DOI: 10.1016/j.bpsc.2024.12.017.Peer-Reviewed Original ResearchFunctional magnetic resonance imaging studyBetween-network functional connectivityTrauma-related psychopathologyEffects of combat deploymentBetween-network connectivityVentral attention networkBrain functional architectureFunctional brain networksMagnetic resonance imaging studiesFunctional network architectureCognitive controlCombat exposureNeural basisBrain networksCombat deploymentFunctional connectivityResilient individualsGroup of university studentsResilient participantsAttention networkNeural adaptationSignificant groupComparison groupLongitudinal studyFunctional architecturePattern integration and differentiation: Dual process model of episodic memory
Evensmoen H, Rimol L, Rise H, Hansen T, Nili H, Winkler A, Håberg A. Pattern integration and differentiation: Dual process model of episodic memory. Imaging Neuroscience 2025, 3: imag_a_00433. DOI: 10.1162/imag_a_00433.Peer-Reviewed Original ResearchEpisodic memoryBrain regionsAssociated with successful memoryModels of episodic memoryHuman episodic memoryDual-process modelActivity patternsSubsequent memoryAnterior hippocampusPosterior hippocampusSuccessful memoryEpisodic orderParticipation episodesObject presentationMemoryHippocampusTemporal compressionBrainEpisodesParticipantsPattern integrityFMRIItems
2024
Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents
Kanel D, Zugman A, Stohr G, Scheinberg B, Cardinale E, Winkler A, Kircanski K, Fox N, Brotman M, Linke J, Pine D. Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents. Journal Of Mood And Anxiety Disorders 2024, 9: 100094. PMID: 39758557, PMCID: PMC11694614, DOI: 10.1016/j.xjmad.2024.100094.Peer-Reviewed Original ResearchStructure-function couplingNegative affectFronto-parietal control networkMeasures of psychopathologyDevelopment of psychopathologyResting-state functional MRIDomain-specific factorsTreatment-seeking youthGroup of adolescentsMultimodal MRI methodsTransdiagnostic groupsFunctional network reorganizationBifactor modelPsychopathologyFunctional MRIFunctional connectivityBrain connectivityStudy of brain connectivityPsychological outcomesFunctional connectivity matricesControl networkNetwork reorganizationAffectAdolescentsAnxietyLongitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Roelofs E, Bas-Hoogendam J, Winkler A, van der Wee N, Vermeiren R. Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders. Neuroscience Applied 2024, 3: 104090. PMID: 39634556, PMCID: PMC11615185, DOI: 10.1016/j.nsa.2024.104090.Peer-Reviewed Original ResearchRight laterobasal amygdalaLaterobasal amygdalaWhole-brain networksAmygdala subregionsFunctional connectivityCentromedial amygdalaSymptom changeFrontal poleInternalizing disordersPostcentral gyrusResting-state functional magnetic resonance imagingResting-state functional connectivityFunctional magnetic resonance imagingICA-derived networksClinically representative sampleFC developmentNonspecific treatment effectsRs-fMRI scansIndependent component analysisResting-state networksLongitudinal developmentCare-as-usualComorbid anxietyNeuroimaging researchBilateral seedsTopological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement
L. S, Seguin C, Winkler A, Noble S, Zalesky A. Topological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement. Network Neuroscience 2024, 8: 902-925. PMID: 39355436, PMCID: PMC11424043, DOI: 10.1162/netn_a_00375.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAbstract Functional magnetic resonance imagingBrain activityAnatomical connectivity informationMedium-sized effectsCluster-based inferenceMultimodal informationConnectivity informationAnatomical underpinningsActive inferenceNeuroimaging analysisAnatomical networksDiffusion tractographyOptimal inferenceInsufficient statistical powerWidespread activationMagnetic resonance imagingFunctional imagingConventional approachesDetect local changesInferenceBrainResonance imagingStatistical powerUsabilityTask–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms
Lee Y, Yuan J, Winkler A, Kircanski K, Pine D, Gotlib I. Task–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 290-300. PMID: 38878818, PMCID: PMC11638404, DOI: 10.1016/j.jaac.2024.04.018.Peer-Reviewed Original ResearchEarly life stressReward networkDepressive symptomsLife stressReconfiguration efficiencyFunctional connectivityExperiences of early life stressExposure to early life stressEffects of early life stressTask-based fMRI scansHigher levels of depressive symptomsLevels of depressive symptomsSevere early life stressReward processingAge-related associationsFMRI scanningAdolescent depressionCommunity sampleTask demandsResting-stateAsymptomatic youthOlder adolescentsEffects of ageRewardBrain statesResting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome
Ansari A, Pillay K, Arasteh E, Dereymaeker A, Mellado G, Jansen K, Winkler A, Naulaers G, Bhatt A, Van Huffel S, Hartley C, De Vos M, Slater R, Baxter L. Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome. Clinical Neurophysiology 2024, 163: 226-235. PMID: 38797002, PMCID: PMC11250083, DOI: 10.1016/j.clinph.2024.05.002.Peer-Reviewed Original ResearchNeurodevelopmental outcomesResting state EEG dataBayley Scales of InfantAbnormal outcome groupsClinical sitesResting-state EEG activityPostmenstrual agePreterm neonatesOutcome groupNeonatesEEG activityBrain age gapElectroencephalographic brain activityBrain agingWeeksEEG dataGap magnitudeOutcomesBrainAgeIndependent datasetsPretermBSIDBrain activityInfantsNeural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study
Filippi C, Winkler A, Kanel D, Elison J, Hardiman H, Sylvester C, Pine D, Fox N. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 905-914. PMID: 38641209, PMCID: PMC11381178, DOI: 10.1016/j.bpsc.2024.03.008.Peer-Reviewed Original ResearchBrain-behavior associationsParent-report measuresInfant temperamentNetwork pairsDorsal attention network connectivityAssessment of infant temperamentParent-reported temperamentAttention network connectivityControl network connectivitySocial anxietyFMRI studyNeural correlatesNeural basisFunctional connectivityParent reportNeuroimaging dataTemperamentAttention-controlComposite scoreDistressNetwork connectivityObservational assessmentNegative associationBehavior estimationDorsal