2023
Structural and functional asymmetry of the neonatal cerebral cortex
Williams L, Fitzgibbon S, Bozek J, Winkler A, Dimitrova R, Poppe T, Schuh A, Makropoulos A, Cupitt J, O’Muircheartaigh J, Duff E, Cordero-Grande L, Price A, Hajnal J, Rueckert D, Smith S, Edwards A, Robinson E. Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour 2023, 7: 942-955. PMID: 36928781, DOI: 10.1038/s41562-023-01542-8.Peer-Reviewed Original ResearchConceptsCortical asymmetryHealthy term-born neonatesNeonatal cerebral cortexTerm-born neonatesTerm-equivalent ageHealthy young adultsHuman Connectome ProjectPreterm birthPreterm neonatesNeonatal cortexCerebral cortexTerm cohortFunctional magnetic resonance imagesMagnetic resonance imagesConnectome ProjectBrain asymmetryYoung adultsSignificant differencesNeonatesResonance imagesFunctional asymmetryCortexBirthBiological sexCohort
2021
An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue
Tackley G, Kong Y, Minne R, Messina S, Winkler A, Cavey A, Everett R, DeLuca G, Weir A, Craner M, Tracey I, Palace J, Stagg C, Emir U. An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 2021, 238: 118225. PMID: 34062267, PMCID: PMC7611458, DOI: 10.1016/j.neuroimage.2021.118225.Peer-Reviewed Original ResearchConceptsTotal N-acetylaspartateMultiple sclerosisN-acetylaspartateBrain lesionsPositive neuromyelitis optica spectrum disorderWhite matterNeuromyelitis optica spectrum disorderOptica spectrum disorderChronic multiple sclerosisPost-hoc testingBrain white matterDisease groupMRS methodologyMRS profilesMRS studiesReciprocal findingsNon-invasive quantificationBrain tissueLesionsMagnetic resonance spectroscopyMyo-inositolDistinct diseasesNormal tissuesCNS moleculesIn-Vivo
2020
Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipantsMinimal Relationship between Local Gyrification and General Cognitive Ability in Humans
Mathias S, Knowles E, Mollon J, Rodrigue A, Koenis M, Alexander-Bloch A, Winkler A, Olvera R, Duggirala R, Göring H, Curran J, Fox P, Almasy L, Blangero J, Glahn D. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cerebral Cortex 2020, 30: 3439-3450. PMID: 32037459, PMCID: PMC7233007, DOI: 10.1093/cercor/bhz319.Peer-Reviewed Original ResearchConceptsGeneral cognitive abilityCognitive abilitiesLocal gyrificationSuperior cognitive abilitiesCortical surface pointsNeurobiology of intelligenceCognitive testsNeuroimaging studiesNeuroanatomical variablesStructural brain imagesMinimal relationshipCortical regionsEffect sizeGyrificationPrevious studiesAbilityNeurobiologyBrain imagesIntelligenceRelationshipHumansIndividualsPotential issuesImplicationsProfound implications
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samplesAccelerated estimation and permutation inference for ACE modeling
Chen X, Formisano E, Blokland G, Strike L, McMahon K, de Zubicaray G, Thompson P, Wright M, Winkler A, Ge T, Nichols T. Accelerated estimation and permutation inference for ACE modeling. Human Brain Mapping 2019, 40: 3488-3507. PMID: 31037793, PMCID: PMC6680147, DOI: 10.1002/hbm.24611.Peer-Reviewed Original ResearchConceptsPermutation inferenceIterative optimizationVariance component modelComputation timeComparable biasAccelerated estimationLinear modelSquared errorCluster sizeSpatial statisticsLinear regression modelsFalse positive riskInferenceHeritability estimationEstimationComponent modelModelWealth of toolsMemory datasetsOptimizationSimple methodSmall numberStatisticsACE modelPermutationsStrategy-dependent modulation of cortical pain circuits for the attenuation of pain
Schulz E, Stankewitz A, Witkovský V, Winkler A, Tracey I. Strategy-dependent modulation of cortical pain circuits for the attenuation of pain. Cortex 2019, 113: 255-266. PMID: 30711854, DOI: 10.1016/j.cortex.2018.12.014.Peer-Reviewed Original ResearchConceptsCognitive strategiesBrain activityDifferent cognitive strategiesPain attenuationUnderlying neuronal mechanismsPain-related brain activityVariability of performanceNeuroscientific techniquesNeurofeedback techniquesT fMRIPerception of painBehavioral dataBehavioral studiesTrial levelBrain regionsCortical regionsNeuronal mechanismsCortical feedbackInsular cortexDistractionTaskPain perceptionPotential predispositionAttenuation of painPerception
2017
The heritability of multi-modal connectivity in human brain activity
Colclough G, Smith S, Nichols T, Winkler A, Sotiropoulos S, Glasser M, Van Essen D, Woolrich M. The heritability of multi-modal connectivity in human brain activity. ELife 2017, 6: e20178. PMID: 28745584, PMCID: PMC5621837, DOI: 10.7554/elife.20178.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectivity profilesNeuronal activityResonance imagingCortical regionsFunctional connectivityFMRI connectivityGenetic factorsConnectivity profilesMagnetoencephalographic recordingsBrain activityCognitive performanceHuman brain activityHuman Connectome ProjectMulti-modal connectivityConnectome ProjectDiseaseAnxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity
van der Meer D, Hoekstra P, van Rooij D, Winkler A, van Ewijk H, Heslenfeld D, Oosterlaan J, Faraone S, Franke B, Buitelaar J, Hartman C. Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity. The World Journal Of Biological Psychiatry 2017, 19: 450-460. PMID: 28635543, PMCID: PMC5581282, DOI: 10.1080/15622975.2017.1287952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyAnxiety DisordersAttention Deficit Disorder with HyperactivityCerebellumChildCognitive DysfunctionCohort StudiesComorbidityCorpus StriatumFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMemory, Short-TermSeverity of Illness IndexThalamusYoung AdultConceptsAttention-deficit/hyperactivity disorderCo-occurring anxietyADHD severityNeural activityMemory taskAttention-deficit/hyperactivity disorder severityMemory-related brain activityPresence of ADHDVisuospatial Working Memory TaskWorking Memory TaskLevel of anxietyVSWM tasksMemory loadHyperactivity disorderTask accuracyPrevious theorisingAnxiety severityBrain activityNeurobiological heterogeneityDisorder severityAnxietyWorse performanceInformation gatingYoung adultsNeural pathways
2016
Investigating resting-state functional connectivity in the cervical spinal cord at 3T
Eippert F, Kong Y, Winkler A, Andersson J, Finsterbusch J, Büchel C, Brooks J, Tracey I. Investigating resting-state functional connectivity in the cervical spinal cord at 3T. NeuroImage 2016, 147: 589-601. PMID: 28027960, PMCID: PMC5315056, DOI: 10.1016/j.neuroimage.2016.12.072.Peer-Reviewed Original ResearchConceptsCervical spinal cordSpinal cord injurySpinal cordVentral hornCord injuryResting-state functional connectivityMagnetic resonance imaging studyResting-state connectivityResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent signalHealthy human participantsNon-human primatesDorsal hornDisease progressionTreatment responseEffects of pathologyNeurological conditionsSpinal segmentsResting-state signalsImaging studiesCordFunctional connectivitySpinal componentsSpontaneous fluctuationsTime related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation
Klaassens B, Rombouts S, Winkler A, van Gorsel H, van der Grond J, van Gerven J. Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human Brain Mapping 2016, 38: 308-325. PMID: 27622387, PMCID: PMC5215384, DOI: 10.1002/hbm.23362.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingCholinergic AgentsCholinesterase InhibitorsCitalopramCross-Over StudiesDouble-Blind MethodFemaleGalantamineHumansHydrocortisoneImage Processing, Computer-AssistedMaleModels, NeurologicalOxygenProlactinSelective Serotonin Reuptake InhibitorsSerotoninYoung AdultConceptsFunctional magnetic resonance imagingState functional magnetic resonance imagingSelf-referential mechanismCognitive performanceNeurotransmitter systemsVisual perceptionAcetylcholinesterase inhibitor galantamineSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramFunctional connectivityRs-fMRI scansSensorimotor networkReuptake inhibitor citalopramBrain neurotransmitter systemsFunctional networksPsychopharmacological researchHealthy young volunteersTime-specific effectsMagnetic resonance imagingGroup comparisonsState networksCrossover studySerotonergic stimulationAcute influenceHeart rateHeterochronicity of white matter development and aging explains regional patient control differences in schizophrenia
Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla D, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O'Donnell P, Xie Z, Paciga S, Schubert C, Chen J, Zhang G, Thompson P, Nichols T, Hong L. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping 2016, 37: 4673-4688. PMID: 27477775, PMCID: PMC5118078, DOI: 10.1002/hbm.23336.Peer-Reviewed Original ResearchConceptsAge-related declineWhite matterSchizophrenia patientsFractional anisotropyFA valuesDiagnosis interactionFaster age-related declinePathophysiology of schizophreniaHum Brain MappEffect of diagnosisLower fractional anisotropyPatient-control differencesT Siemens MRI scannerBrain white matterClinical burdenRegional FA valuesPatientsAbnormal rateBrain connectivityTract developmentAdolescent maturationSpecific tractsRegional reductionDiagnosisSchizophreniaA comprehensive tractography study of patients with bipolar disorder and their unaffected siblings
Sprooten E, Barrett J, McKay DR, Knowles EE, Mathias SR, Winkler AM, Brumbaugh MS, Landau S, Cyr L, Kochunov P, Glahn DC. A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings. Human Brain Mapping 2016, 37: 3474-3485. PMID: 27198848, PMCID: PMC5496097, DOI: 10.1002/hbm.23253.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBipolar DisorderBrainComorbidityDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedMaleNeural PathwaysOrgan SizePattern Recognition, AutomatedPsychiatric Status Rating ScalesSeverity of Illness IndexSiblingsYoung Adult
2015
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects
Kochunov P, Thompson P, Winkler A, Morrissey M, Fu M, Coyle T, Du X, Muellerklein F, Savransky A, Gaudiot C, Sampath H, Eskandar G, Jahanshad N, Patel B, Rowland L, Nichols T, O'Connell J, Shuldiner A, Mitchell B, Hong L. The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. NeuroImage 2015, 125: 189-197. PMID: 26499807, PMCID: PMC4691385, DOI: 10.1016/j.neuroimage.2015.10.050.Peer-Reviewed Original ResearchA positive-negative mode of population covariation links brain connectivity, demographics and behavior
Smith S, Nichols T, Vidaurre D, Winkler A, Behrens T, Glasser M, Ugurbil K, Barch D, Van Essen D, Miller K. A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nature Neuroscience 2015, 18: 1565-1567. PMID: 26414616, PMCID: PMC4625579, DOI: 10.1038/nn.4125.Peer-Reviewed Original ResearchMulti-level block permutation
Winkler AM, Webster MA, Vidaurre D, Nichols TE, Smith SM. Multi-level block permutation. NeuroImage 2015, 123: 253-268. PMID: 26074200, PMCID: PMC4644991, DOI: 10.1016/j.neuroimage.2015.05.092.Peer-Reviewed Original ResearchHeritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Kochunov P, Jahanshad N, Marcus D, Winkler A, Sprooten E, Nichols TE, Wright SN, Hong LE, Patel B, Behrens T, Jbabdi S, Andersson J, Lenglet C, Yacoub E, Moeller S, Auerbach E, Ugurbil K, Sotiropoulos SN, Brouwer RM, Landman B, Lemaitre H, Braber A, Zwiers MP, Ritchie S, van Hulzen K, Almasy L, Curran J, deZubicaray GI, Duggirala R, Fox P, Martin NG, McMahon KL, Mitchell B, Olvera RL, Peterson C, Starr J, Sussmann J, Wardlaw J, Wright M, Boomsma DI, Kahn R, de Geus EJ, Williamson DE, Hariri A, van 't Ent D, Bastin ME, McIntosh A, Deary IJ, pol H, Blangero J, Thompson PM, Glahn DC, Van Essen DC. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage 2015, 111: 300-311. PMID: 25747917, PMCID: PMC4387079, DOI: 10.1016/j.neuroimage.2015.02.050.Peer-Reviewed Original Research
2014
Interaction of brain areas of visual and vestibular simultaneous activity with fMRI
Della-Justina H, Gamba H, Lukasova K, Nucci-da-Silva M, Winkler A, Amaro E. Interaction of brain areas of visual and vestibular simultaneous activity with fMRI. Experimental Brain Research 2014, 233: 237-252. PMID: 25300959, DOI: 10.1007/s00221-014-4107-6.Peer-Reviewed Original ResearchConceptsNegative BOLD responseSimultaneous stimulationPrecentral gyrusBrain areasVestibular systemParieto-insular vestibular cortexVisual stimulationVisual-vestibular stimuliNon-symptomatic subjectsFunctional magnetic resonance imagingMagnetic resonance imagingAssociative visual cortexLevel-dependent responsesSuperior temporal gyrusInferior parietal lobeVestibular cortexCalcarine gyrusInferior frontal gyrusVestibular inputCerebellar hemisphereVestibular stimulationTemporal lobeLingual gyrusParietal lobeAssociation areasAssessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation
2013
Influence of age, sex and genetic factors on the human brain
McKay DR, Knowles EE, Winkler AA, Sprooten E, Kochunov P, Olvera RL, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Duggirala R, Almasy L, Fox PT, Blangero J, Glahn DC. Influence of age, sex and genetic factors on the human brain. Brain Imaging And Behavior 2013, 8: 143-152. PMID: 24297733, PMCID: PMC4011973, DOI: 10.1007/s11682-013-9277-5.Peer-Reviewed Original Research