2022
Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans
Abend R, Burk D, Ruiz S, Gold A, Napoli J, Britton J, Michalska K, Shechner T, Winkler A, Leibenluft E, Pine D, Averbeck B. Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans. ELife 2022, 11: e66169. PMID: 35473766, PMCID: PMC9197395, DOI: 10.7554/elife.66169.Peer-Reviewed Original ResearchConceptsThreat learningAnxiety severitySafety learningNeuroanatomical substratesGreater anxiety severitySkin conductance dataThreat conditioningThreat extinctionThreat generalizationGray matter volumeSafe stimuliAssociative learningComputational mechanismsAnxiety symptomsAnxiety disordersInfluential theoriesSlower extinctionComputational modelLearningWhole brain anatomyAnxietyComputational modelingStructural imagingStimuliTask
2020
Infant behavioral reactivity predicts change in amygdala volume 12 years later
Filippi C, Sachs J, Phillips D, Winkler A, Gold A, Leibenluft E, Pine D, Fox N. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Developmental Cognitive Neuroscience 2020, 42: 100776. PMID: 32452462, PMCID: PMC7096757, DOI: 10.1016/j.dcn.2020.100776.Peer-Reviewed Original ResearchConceptsYears of ageFour-month-old infantsAmygdala volumeBrain developmentAmygdala developmentPositive reactivityBehavioral reactivityStructural imagingInfant temperamentNovel evidenceChildhoodDistinct patternsCurrent studyMiddle childhoodYearsNegative reactivityReactive temperamentTemperamental reactivityInfants