Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistressInfant behavioral reactivity predicts change in amygdala volume 12 years later
Filippi C, Sachs J, Phillips D, Winkler A, Gold A, Leibenluft E, Pine D, Fox N. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Developmental Cognitive Neuroscience 2020, 42: 100776. PMID: 32452462, PMCID: PMC7096757, DOI: 10.1016/j.dcn.2020.100776.Peer-Reviewed Original ResearchConceptsYears of ageFour-month-old infantsAmygdala volumeBrain developmentAmygdala developmentPositive reactivityBehavioral reactivityStructural imagingInfant temperamentNovel evidenceChildhoodDistinct patternsCurrent studyMiddle childhoodYearsNegative reactivityReactive temperamentTemperamental reactivityInfants