2023
Country-level gender inequality is associated with structural differences in the brains of women and men
Zugman A, Alliende L, Medel V, Bethlehem R, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto G, Castro M, Chaim-Avancini T, Compte A, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Di Forti M, Díaz-Caneja C, Díaz-Zuluaga A, Du Plessis S, Duran F, Fittipaldi S, Fornito A, Freimer N, Gadelha A, Gama C, Garani R, Garcia-Rizo C, Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, López-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan P, Parellada M, Phahladira L, Ramirez-Mahaluf J, Reckziegel R, Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein D, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga E, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown T, Yalin N, Zamorano F, Zanetti M, cVEDA, Winkler A, Pine D, Evans-Lacko S, Crossley N, Murthy P, Chakrabarti A, Basu D, Subodh B, Singh L, Singh R, Kalyanram K, Kartik K, Kumaran K, Krishnaveni G, Kuriyan R, Kurpad S, Barker G, Bharath R, Desrivieres S, Purushottam M, Orfanos D, Sharma E, Hickman M, Heron J, Toledano M, Vaidya N. Country-level gender inequality is associated with structural differences in the brains of women and men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2218782120. PMID: 37155867, PMCID: PMC10193926, DOI: 10.1073/pnas.2218782120.Peer-Reviewed Original ResearchConceptsWorse outcomesCaudal anterior cingulateRight caudal anterior cingulateRight medial orbitofrontalAdult healthy menBrains of womenMental health problemsLateral occipital cortexHealthy menRegional cortexHigh riskOccipital cortexCortical thicknessCountry-level gender inequalityMedial orbitofrontalMRI scansThinner cortexAnterior cingulateHealth problemsBrain structuresWomen's brainsWomenBrainCortexRight hemisphere
2021
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individualsAllocentric representation in the human amygdala and ventral visual stream
Evensmoen H, Rimol L, Winkler A, Betzel R, Hansen T, Nili H, Håberg A. Allocentric representation in the human amygdala and ventral visual stream. Cell Reports 2021, 34: 108658. PMID: 33472067, DOI: 10.1016/j.celrep.2020.108658.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMedial temporal lobeVentral visual streamHigh-resolution functional magnetic resonance imagingMagnetic resonance imagingBrain activation patternsDistinct neural populationsVisual streamMain brain structuresEntorhinal cortexTemporal lobePerirhinal cortexResonance imagingParahippocampal cortexBrain structuresCortexHippocampusAmygdalaFusiform cortexActivation patternsHuman amygdalaYoung menNeural populationsAllocentric representationsConnector hubs
2020
The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure
Sexton C, Betts J, Dennis A, Doherty A, Leeson P, Holloway C, Dall'Armellina E, Winkler A, Demnitz N, Wassenaar T, Dawes H, Johansen-Berg H. The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure. Physiology & Behavior 2020, 223: 112923. PMID: 32474233, PMCID: PMC7378567, DOI: 10.1016/j.physbeh.2020.112923.Peer-Reviewed Original ResearchConceptsAerobic training programGray matter volumeCardiorespiratory fitnessMatter volumeMagnetic resonance imaging outcomesSpecific high-risk populationsBrain structuresOlder adultsAerobic training interventionHigh-risk populationStructural MRI analysisTract-based spatial statisticsVoxel-based morphometryVoxel-wise assessmentWaitlist control conditionHealthy older adultsWhite matter microstructureImaging outcomesHippocampal volumeObservational studyPhysical activityReduced riskCognitive declineMax testingMore encouraging resultsWhite matter structure and myelin-related gene expression alterations with experience in adult rats
Sampaio-Baptista C, Vallès A, Khrapitchev A, Akkermans G, Winkler A, Foxley S, Sibson N, Roberts M, Miller K, Diamond M, Martens G, De Weerd P, Johansen-Berg H. White matter structure and myelin-related gene expression alterations with experience in adult rats. Progress In Neurobiology 2020, 187: 101770. PMID: 32001310, PMCID: PMC7086231, DOI: 10.1016/j.pneurobio.2020.101770.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingAdult ratsMRNA expressionMyelin basic protein mRNA expressionWM plasticityNeuronal activity modulationMBP protein expressionC-fos mRNA expressionMatter structuresAnalysis of myelinGray matter structuresProtein mRNA expressionWhite matter plasticityRegulation of myelinationWhite matter structuresBarrel cortexGene expression alterationsCortical activityMRNA expression analysisRNA sequencing analysisBrain structuresTensor imagingDTI differencesMacroscale measuresMolecular correlates
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samples
2015
Genetic Influence on the Human Brain
McKay D, Winkler A, Kochunov P, Knowles E, Sprooten E, Fox P, Blangero J, Glahn D. Genetic Influence on the Human Brain. Genome Mapping And Genomics In Animals 2015, 247-258. DOI: 10.1007/978-3-662-46306-2_13.Peer-Reviewed Original ResearchProgram of discoveryGenetic elementsGenetic underpinningsBasic neuroscienceBrain functionBrain structuresHuman brainGenetic influencesNeuroscienceNeuroscience componentFundamental neuroscienceGenetic search spacePrevalent disorderOverarching goalDiscoveryGenesSystematic programGeneticsImage-based featuresPhenotypeUnderpinningsMaturationLongevityDisordersImplications