Involvement of Autophagy in Cardiac Remodeling in Transgenic Mice with Cardiac Specific Over-Expression of Human Programmed Cell Death 5
An L, Zhao X, Wu J, Jia J, Zou Y, Guo X, He L, Zhu H. Involvement of Autophagy in Cardiac Remodeling in Transgenic Mice with Cardiac Specific Over-Expression of Human Programmed Cell Death 5. PLOS ONE 2012, 7: e30097. PMID: 22253891, PMCID: PMC3256219, DOI: 10.1371/journal.pone.0030097.Peer-Reviewed Original ResearchConceptsCardiac remodelingTransgenic miceAlpha-myosin heavy chain promoterCell death 5Angiotensin II treatmentTransverse aortic constrictionMyosin heavy chain promoterRole of PDCD5Death 5Reduced survival rateFetal gene programHeavy chain promoterHeart failureControl miceAngiotensin IIHeart weightHistopathological examinationAortic constrictionReal-time RT-PCR analysisInvolvement of autophagyII treatmentCardiac hypertrophyImmunohistochemistry analysisBody weightSurvival rate