2022
Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotonin
2021
Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain
Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf B, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett E, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain. EBioMedicine 2021, 74: 103701. PMID: 34826801, PMCID: PMC8626580, DOI: 10.1016/j.ebiom.2021.103701.Peer-Reviewed Original ResearchConceptsCannabis smokersActinomyces meyeriCannabis smokingCentral nervous systemOral pathobiontsChronic cannabis smokersMacrophage infiltrationCannabis use disorderOral microbiomeOral microbial dysbiosisSaliva microbiomeNon-smoking controlsIncreased macrophage infiltrationCannabis exposureUse disorderMicrobial 16S rRNA sequencingCannabisCNS abnormalitiesProtein productionActinomyces odontolyticusOral bacteriaBehavioral changesNon-smokersMicrobial dysbiosisNervous system
2018
Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection
Xu W, Luo Z, Alekseyenko A, Martin L, Wan Z, Ling B, Qin Z, Heath S, Maas K, Cong X, Jiang W. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific Reports 2018, 8: 12863. PMID: 30150778, PMCID: PMC6110826, DOI: 10.1038/s41598-018-31116-y.Peer-Reviewed Original ResearchConceptsAnti-CD4 IgGVirally suppressive antiretroviral therapyAnti-CD4 autoantibodiesHIV+ subjectsMicrobial translocationAntiretroviral therapyAutoantibody productionPlasma levelsCD4+ T-cell recoveryChronically HIV-1-infected patientsPlasma anti-CD4 IgG levelsHealthy controlsPlasma levels of autoantibodiesHIV-1-infected patientsAssociated with plasma levelsElevated microbial translocationSystemic microbial translocationHIV-infected subjectsT-cell recoveryReduced microbial diversityLevels of autoantibodiesLimulus amebocyte assayHIV infectionPlasma microbiomeHIV disease