Trevor Jeffrey Bush

Chronic inflammatory diseases, such as neurodegeneration and gastrointestinal diseases, are multifactorial in their pathology, driven by many interconnected pathways. Western medicine traditionally focuses on a "one-target, one-drug" model. When you block a single target in such a multifaceted pathology, the body often adapts by utilizing compensatory pathways, resulting in a weakened response to treatment and potentially toxic adverse effects.

Trevor is interested in breaking from this reductionist model by investigating how traditional medicinal herbs from across the world can be applied to treat chronic inflammatory diseases through a polychemical, multi-target (polypharmacological), systems approach.

Another interest includes investigating the understudied dysregulation of complex lipid metabolism in disease for diagnostic and prognostic purposes and the impact of medicinal herb interventions on this dysregulation.

Through his efforts, he hopes to further Professor Yung-Chi Cheng's vision of merging Western and Eastern approaches into “WE Medicine.”

Approaches & Techniques:

• Plant sourcing and preparation

• Bioactivity guided fractionation
• Protein-Ligand Kinetics
• Interaction metabolomics
• Reporter cell lines
• Inducible cell models
• Cellular Thermal Shift Assay (CETSA-MS)
• Hydrogen Deuterium Exchange (HDX-MS)
• Molecular docking and dynamics
• Mouse models
  
• Mass spectrometry spatial omics (Proteomics, Lipidomics, Metabolomics)

• Positron Emission Tomography