Tae Oh, MD
Professor Emeritus of AnesthesiologyCards
About
Research
Publications
2026
Neuroprotective effects of isoflavone-enriched soybean leaves (Glycine Max) on scopolamine-induced memory deficits in C57BL/6 mice via antioxidative mechanisms
Ju Y, Kim S, Go Y, Lee Y, Park K, Oh T. Neuroprotective effects of isoflavone-enriched soybean leaves (Glycine Max) on scopolamine-induced memory deficits in C57BL/6 mice via antioxidative mechanisms. Frontiers In Aging Neuroscience 2026, 18: 1787268. DOI: 10.3389/fnagi.2026.1787268.Peer-Reviewed Original ResearchIsoflavone-enriched soybean leavesMemory-enhancing effectsBrain-derived neurotrophic factorCAMP response element-binding proteinCognitive impairmentScopolamine-induced cognitive impairmentScopolamine-induced memory deficitsCREB-BDNF signaling pathwayExpression of brain-derived neurotrophic factorPassive avoidance testMorris water mazeMemory deficitsWater mazeAvoidance testMemory impairmentBehavioral deficitsResponse element-binding proteinSpatial learningMemory functionC57BL/6 miceNeuroprotective effectsNeurotrophic factorElement-binding proteinIntracellular accumulationImpairment
2025
Novel intranasal delivery of sihosogansan demonstrates rapid antidepressant activity via GABAergic and BDNF/TrkB pathways: identification of potential bioactive quality markers
Tran K, Munni Y, Nguyen L, Oh T, Choi H, Moon I, Yang I. Novel intranasal delivery of sihosogansan demonstrates rapid antidepressant activity via GABAergic and BDNF/TrkB pathways: identification of potential bioactive quality markers. Chinese Medicine 2025, 20: 162. PMID: 41047379, PMCID: PMC12498446, DOI: 10.1186/s13020-025-01219-6.Peer-Reviewed Original ResearchAntidepressant effectsGamma-aminobutyric acid (GABA)ergic signalingOral administrationAntidepressant-like effectsTail suspension testGlutamate decarboxylase 67Prolonged treatment periodSignal-regulated protein kinaseEEG abnormalitiesIntranasal deliverySuspension testAntidepressant activityTrkB pathwayBDNF/TrkB pathwayGABA levelsMolecular studiesTreatment periodReceptor signalingHippocampal tissueGABAB1 receptorTheta/beta ratioPost-administrationAnxiety modelsMolecular assaysConclusionThese findings2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity
Munni Y, Tran K, Jeon S, Hwang M, Yoon J, Song Y, Oh T, Gum S, Yang I. 2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity. Frontiers In Pharmacology 2025, 16: 1598030. PMID: 40918527, PMCID: PMC12408522, DOI: 10.3389/fphar.2025.1598030.Peer-Reviewed Original ResearchPrimary hippocampal neuronsY-maze testWater mazeY-mazeCognitive performanceSynaptic vesicle protein 2Synaptic vesicle recyclingMouse model of ADAlzheimer's diseaseHuman milk oligosaccharidesRelevant to ADDisorder complexitySynaptic plasticityCytokine levels in vivoMouse modelModel of ADOxidative stressAD-related cognitive declineMorris water mazeInterleukin (IL)-6 levelsTumor necrosis factor (TNF)-aBrain-derived neurotrophic factorShortened escape latencyVesicle recyclingPostsynaptic density protein 95Protective effects of Dioscoreabulbifera and Zingiber officinale mixed extracts against glutamate-induced cell death in HT22 cells
Im S, Jeong W, Lee D, Oh T. Protective effects of Dioscoreabulbifera and Zingiber officinale mixed extracts against glutamate-induced cell death in HT22 cells. Applied Biological Chemistry 2025, 68: 53. DOI: 10.1186/s13765-025-01026-5.Peer-Reviewed Original ResearchReactive oxygen speciesPI3K/AKT/mTOR survival pathwayGlutamate-induced cell deathMAPK signaling cascadeHT-22 cellsProtective effectMixed extractantSurvival pathwaysCaspase-3Signaling cascadesCell deathGlutamate-induced neuronal deathWestern blot analysisNeuroprotective effectsRegulating oxidative stressMolecular mechanismsHT22 cellsApoptotic markersGlutamate-induced excitotoxicityHT-22Blot analysisAntioxidant capacityCellular morphologyConcentration-dependent mannerOxygen speciesThe role of tight junctions in the pathogenesis of inflammatory bowel disease: immune modulation and barrier dysfunction
Heo J, Kim M, Yang Y, Choi H, Kim K, Oh T, Yang J, Kim Y, Park K. The role of tight junctions in the pathogenesis of inflammatory bowel disease: immune modulation and barrier dysfunction. Molecular & Cellular Toxicology 2025, 21: 495-506. DOI: 10.1007/s13273-025-00545-y.Peer-Reviewed Original ResearchInflammatory bowel diseaseIncreased epithelial permeabilityPathogenesis of inflammatory bowel diseaseBowel diseaseTight junctionsEpithelial permeabilityDisease progressionTherapeutic strategiesDisruption of tight junctionsRelease of proinflammatory cytokinesTumor necrosis factor-alphaPathophysiology of inflammatory bowel diseaseTight junction dysfunctionTight junction regulationTight junction disruptionTight junction integrityTight junction structureImmune cell activationMucosal immune systemRegulate paracellular transportNecrosis factor-alphaIntestinal tight junctionsInflammatory bowel disease managementNuclear factor kappa BInterleukin-1 beta
2024
Anti-neuroinflammatory effects of the KIOM -patented Polygonum multiflorum maximized root tuber against LPS-stimulated BV2 Cells
Oh T, Ban Y, Kang Y. Anti-neuroinflammatory effects of the KIOM -patented Polygonum multiflorum maximized root tuber against LPS-stimulated BV2 Cells. Applied Biological Chemistry 2024, 67: 71. DOI: 10.1186/s13765-024-00928-0.Peer-Reviewed Original ResearchHigher content of active ingredientP. multiflorumMouse microglial BV-2 cellsLPS-stimulated BV2 cellsContent of active ingredientsTranscription factor activityAnti-neuroinflammatory effectsMitogen-activated protein kinaseMechanisms of neurodegenerationActivation of p38Pathological mechanisms of neurodegenerationMicroglial BV-2 cellsHigher contentIncreased biomassRoot tubersBV2 cellsAntioxidant effectsCultivation conditionsProtein kinaseOriental medicinal herbRegulation mechanismBV-2 cellsInducible NO synthaseMAPK phosphorylationMedicinal herbsAntioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro
Bae S, Lee W, Bak S, Lee S, Hwang S, Kim G, Koo B, Park S, Yoo H, Kim C, Kang H, Oh T, Kim Y. Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro. International Journal Of Molecular Sciences 2024, 25: 2313. PMID: 38396988, PMCID: PMC10889506, DOI: 10.3390/ijms25042313.Peer-Reviewed Original ResearchConceptsFormation of neurofibrillary tanglesNeurofibrillary tanglesAlzheimer's diseaseImpaired clearance of amyloid betaSignaling pathwayClearance of amyloid betaAMPK Signaling PathwayActivate signaling pathwaysAlzheimer's disease in vivoInhibition of cell apoptosisCause of dementiaAmyloid-betaHT-22 cellsNeuritic plaquesIn vitroMitochondrial dysfunctionOxidative stressCell apoptosisDisease in vivoROS generationHT-22Prevent ADAMPKDisorders in vivoProtein levels
2020
Acer tegmentosum Maxim Prevents Bone Loss by Inhibiting Osteoclastogenesis and Promoting Osteoblast Mineralization in Ovariectomized Mice
Oh T, Park K, Do H, Kim K, Yang H, Cho W, Ma J. Acer tegmentosum Maxim Prevents Bone Loss by Inhibiting Osteoclastogenesis and Promoting Osteoblast Mineralization in Ovariectomized Mice. Natural Product Sciences 2020, 26: 83-89. DOI: 10.20307/nps.2020.26.1.83.Peer-Reviewed Original Research
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