2010
Aplidin as a potential adjunct to radiation therapy: In vitro studies
Rockwell S, Liu Y. Aplidin as a potential adjunct to radiation therapy: In vitro studies. International Journal Of Radiation Biology 2010, 86: 63-70. PMID: 20070217, PMCID: PMC2837581, DOI: 10.3109/09553000903264531.Peer-Reviewed Original ResearchConceptsH drug treatmentDrug treatmentPhase II clinical trialEMT6 mouse mammary tumor cellsGy of radiationMouse mammary tumor cellsMammary tumor cellsBystander effectSupraadditive cytotoxicityTherapeutic regimensHematologic malignanciesClinical trialsRadiation therapyModerate hypoxiaActive metaboliteSevere hypoxiaTumor cellsUntreated cellsTreatmentCytotoxicityHypoxiaAplidinKV X-raysCellsMonolayer cultures
2009
Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. 2009, 9: 442-58. PMID: 19519402, PMCID: PMC2752413, DOI: 10.2174/156652409788167087.Peer-Reviewed Original ResearchConceptsClinical trialsSolid tumorsLarge bulky tumorsMicroscopic tumor involvementSmall primary tumorsSelection of patientsOutcome of treatmentNovel therapeutic approachesNew therapeutic targetsEffects of hypoxiaHypoxic tumor cellsTumor oxygen levelsSurgical marginsTumor involvementBulky tumorsTreatment regimensPrimary tumorVascular bedClinical studiesExtensive necrosisRadiation therapyTherapeutic approachesNew agentsTherapeutic targetTherapeutic resistance
1999
The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation.
Rosen E, Fan S, Rockwell S, Goldberg I. The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Investigation 1999, 17: 56-72. PMID: 10999050, DOI: 10.3109/07357909909011718.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCell CycleCell Cycle ProteinsCell Transformation, NeoplasticCellsCHO CellsCricetinaeCytokinesDNADNA DamageDNA RepairDNA-Binding ProteinsGenesGenes, BRCA1Genes, p53Growth SubstancesHumansNeoplasmsNeoplasms, Radiation-InducedOncogene ProteinsOncogenesProtein Serine-Threonine KinasesRadiation ToleranceRadiotherapySignal TransductionTime FactorsTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsGrowth factor signal transductionDNA damage responseCell cycle progressionCellular functionsDamage responseSignal transductionOverexpress proteinsCandidate genesCycle progressionMolecular mechanismsGenetic instabilityFunction mutationsCell typesCellular radiosensitivityCellular basisCellular mechanismsNormal tissuesGenesMutationsRadiosensitivityRecent studiesSevere normal tissue damageMild effectIndividual tumorsTransduction