Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study
McNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.Peer-Reviewed Original ResearchConceptsDEF ratsFO ratsAMPH challengeAmphetamine treatmentDocosahexaenoic acidBOLD activationDHA levelsBilateral caudate putamenBrain DHA levelsErythrocyte DHA levelsNeuroplastic brain changesPharmacological magnetic resonanceBlood oxygen level-dependent (BOLD) responseAlpha-linolenic acidAttention deficit hyperactivity disorderLevel-dependent responsesGreater locomotor activityDeficit hyperactivity disorderDEF animalsBrain activation patternsPhMRI studiesAMPH injectionFatty acidsAMPH exposureBasal forebrainDeficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale ratsGlutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study
McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.Peer-Reviewed Original ResearchConceptsDEF ratsGlutamate homeostasisPrefrontal cortexFO ratsDHA levelsAdult rat prefrontal cortexVivo 1H MRS studyMarkers of excitotoxicityFatty acid-deficient dietAstrocyte glutamate transportersH-MRS scansAdult rat brainRat prefrontal cortexAdult prefrontal cortexGlutamine/glutamate ratioDietary-induced alterationsMajor psychiatric disordersBrain DHAGlutamate levelsDiet groupGLAST expressionGlutamine synthetase expressionMRS scansAdolescent ratsRat brain