Raul J Guzman, MD
Donald Guthrie Professor of Vascular Surgery, Vice Chair, Faculty AffairsCards
About
Research
Publications
2025
Authors' Reply: Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification
Jin Y, Guzman R, Cai Y. Authors' Reply: Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification. Journal Of The American Society Of Nephrology 2025 DOI: 10.1681/asn.0000000972.Peer-Reviewed Original ResearchSmoking cessation duration is associated with the risk of amputation after revascularization for chronic limb-threatening ischemia Presented at the Annual Spring Meeting of the Vascular and Endovascular Surgery Society, New Orleans, LA, June 4, 2025.
Carter W, Schwartz A, Sumpio B, Strosberg D, Tonnessen B, Cardella J, Guzman R, Chaar C. Smoking cessation duration is associated with the risk of amputation after revascularization for chronic limb-threatening ischemia Presented at the Annual Spring Meeting of the Vascular and Endovascular Surgery Society, New Orleans, LA, June 4, 2025. European Journal Of Vascular And Endovascular Surgery 2025, 70: e308-e309. DOI: 10.1016/j.ejvs.2025.11.022.Peer-Reviewed Original ResearchAuthors' Reply: A Calciprotein Particle–Centric Framework for Vascular Calcification in CKD Models
Jin Y, Guzman R, Cai Y. Authors' Reply: A Calciprotein Particle–Centric Framework for Vascular Calcification in CKD Models. Journal Of The American Society Of Nephrology 2025 DOI: 10.1681/asn.0000000937.Peer-Reviewed Original ResearchAortic calcification is associated with decreased abdominal aortic aneurysm growth
Olson S, Kostiuk V, Kim T, Curci J, Baxter T, Matsumura J, Blackwelder W, Terrin M, Guzman R. Aortic calcification is associated with decreased abdominal aortic aneurysm growth. Scientific Reports 2025, 15: 39112. PMID: 41203851, PMCID: PMC12594760, DOI: 10.1038/s41598-025-26407-0.Peer-Reviewed Original ResearchConceptsNon-invasive treatmentAortic calcificationNon-Invasive Treatment of Abdominal Aortic Aneurysm Clinical TrialProspective multicenter randomized studyRate of aneurysm growthAneurysm growthNon-Contrast Computed TomographySecondary cohort analysisAbdominal aortic calcificationBaseline calcium scoreAbdominal aortic aneurysm growthMulticenter randomized studyAortic aneurysm growthCause of morbidityAbdominal aortic aneurysm (AAA) ruptureSuperior mesenteric arteryMaximum transverse diameterCalcium scoreAgatston scoreCalcium burdenRandomized patientsRandomized studyMesenteric arteryUnivariate analysisRenal arteryHigh Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice.
Jin Y, Cao F, Xie Y, Davis S, Dong G, Nigwekar S, Hansen J, Guzman R, Cai Y. High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice. Journal Of The American Society Of Nephrology 2025 PMID: 40960881, PMCID: PMC12448113, DOI: 10.1681/asn.0000000875.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease miceCutaneous vascular calcificationArteriolar calcificationVascular calcificationP38 MAPK signalingMedial arterial calcificationPharmacological inhibition of p38 MAPK signalingArtery calcificationLow-protein dietPharmacological inhibitionMedial arteryInhibition of p38 MAPK signalingCKD mouse modelMolecular pathwaysMAPK signalingExperimental CKD modelsPharmacological inhibitor SB203580Kidney impairmentAlizarin red stainingNephrectomy miceSignaling in vivoVascular complicationsKidney dysfunctionTreatment strategiesSmoking cessation duration is associated with the risk of amputation after revascularization for chronic limb-threatening ischemia
Carter W, Schwartz A, Sumpio B, Strosberg D, Tonnessen B, Cardella J, Guzman R, Ochoa Chaar C. Smoking cessation duration is associated with the risk of amputation after revascularization for chronic limb-threatening ischemia. Journal Of Vascular Surgery 2025, 83: 256-264.e2. PMID: 40912340, DOI: 10.1016/j.jvs.2025.08.037.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaCurrent smokersFormer smokersSmoking cessationMajor amputationLower extremity revascularizationCessation durationLimb-threatening ischemiaDuration of smoking cessationQuality InitiativeStandardized follow-up periodsRisk of amputationSmoking cessation durationVascular Quality InitiativeFormer smokingCurrent smokingPerioperative outcomesBlack racePeripheral vascular interventionsAmputationSmokingEnd-stage renal diseaseMonths of surgeryKaplan-Meier analysisFollow-up periodSmoking Cessation After Carotid Revascularization in the Vascular Quality Initiative
Schwartz A, Carter W, Zwibelman H, Lemmon G, Cardella J, Dardik A, Guzman R, Chaar C. Smoking Cessation After Carotid Revascularization in the Vascular Quality Initiative. Journal Of Vascular Surgery 2025, 82: e46-e47. DOI: 10.1016/j.jvs.2025.05.199.Peer-Reviewed Original ResearchTiming of outpatient stenting is associated with stent size in nonthrombotic iliac vein lesions
Schultz K, Rodriguez P, Ali S, Attaran R, Lozada J, Huber S, Tonnessen B, Aboian E, Guzman R, Chaar C. Timing of outpatient stenting is associated with stent size in nonthrombotic iliac vein lesions. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2025, 14: 102303. PMID: 40850563, PMCID: PMC12495162, DOI: 10.1016/j.jvsv.2025.102303.Peer-Reviewed Original ResearchNonthrombotic iliac vein lesionsIliac vein lesionsVein lesionsLate cohortStent sizeStent placementRetrospective studyRetrospective study of patientsMultivariate logistic regression analysisTime of stentingIliac vein stentingDay of surgeryStudy of patientsFirst-time treatmentEarly cohortMultivariate logistic regressionLogistic regression analysisIntravascular ultrasound examinationVein stentingVenous stentingStenting timeBaseline characteristicsUltrasound examinationVolume deficitsSmall stentsFrailty and functional decline after elective endovascular abdominal aortic aneurysm repair in octogenarians
Li J, Slade M, Gill T, Bader J, Guzman R, Tonnessen B, Kuwayama D, Dardik A, Cardella J, Ochoa Chaar C. Frailty and functional decline after elective endovascular abdominal aortic aneurysm repair in octogenarians. Journal Of Vascular Surgery 2025, 83: 79-90.e2. PMID: 40835162, DOI: 10.1016/j.jvs.2025.08.011.Peer-Reviewed Original ResearchElective endovascular abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairAbdominal aortic aneurysm repairAortic aneurysm repairModified Frailty IndexFollow-upRisk Analysis IndexRisk factorsAneurysm repairValidation cohortDevelopment cohortEastern Cooperative Oncology Group performance statusAsymptomatic infrarenal abdominal aortic aneurysmFunctional declineInfrarenal abdominal aortic aneurysmVascular Quality Initiative (VQI) databaseFrailty assessmentCongestive heart failureAbdominal aortic aneurysmLong-term mortality riskChronic obstructive pulmonary diseaseFrailty indexObstructive pulmonary diseasePreoperative factorsPreoperative comorbiditiesPilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease
Kim T, Brahmandam A, Alameddine D, Forman R, Hardik A, Fucito L, Mena-Hurtado C, Guzman R, Chaar C. Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease. Journal Of Vascular Surgery 2025, 82: a20. DOI: 10.1016/j.jvs.2025.05.139.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Dr. Raul Guzman is chief of the division of vascular surgery and endovascular therapy at Yale New Haven Hospital. He is also surgeon-in-chief, vascular surgery at the Heart and Vascular Center for the Yale New Haven Health System.
Dr. Guzman joins Yale Medicine from Beth Israel Deaconess Medical Center and Harvard Medical School. Prior to moving to Boston, he spent the early portion of his career at Vanderbilt Medical Center in Nashville, Tennessee, where he served for several years as chief of vascular surgery at the Nashville VA Hospital.
He received his medical degree from Johns Hopkins University in Baltimore, MD. After completing his residency in general surgery, he completed research training in the cardiology branch of the National Heart, Lung, and Blood Institute at the National Institutes of Health (NIH) and subsequently completed a fellowship in vascular surgery at Stanford University Hospital.
He recently completed his term as a permanent member of the Bioengineering, Technology, and Surgical Sciences Study Section of the NIH. His clinical interests relate to patients who have diabetic vascular disease, peripheral artery disease, and preventing amputation. His research focuses on the role of arterial calcification in lower extremity ischemia.
Clinical Specialties
Vascular & Endovascular Surgery
Fact Sheets
Vascular Surgery
Learn More on Yale MedicinePeripheral Artery Disease (PAD)
Learn More on Yale MedicineAortic Aneurysm
Learn More on Yale MedicinePeripheral Vascular Disease (PVD)
Learn More on Yale Medicine
Yale Medicine News
News
News
- December 18, 2025
Yale Surgery Team Marks Milestone with 100th Complex Endovascular Aortic Repair
- December 12, 2024
Yale Vascular Surgery Launches Same-Day Dialysis Access Program
- December 12, 2024
Dr. Raul Guzman Receives the 2024 Dr. Walter E. Longo MD Award
- June 03, 2024
Vascular Innovates Sedation Model to Alleviate OR Capacity
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