2001
Development of Layer I Neurons in the Primate Cerebral Cortex
Zecevic N, Rakic P. Development of Layer I Neurons in the Primate Cerebral Cortex. Journal Of Neuroscience 2001, 21: 5607-5619. PMID: 11466432, PMCID: PMC6762645, DOI: 10.1523/jneurosci.21-15-05607.2001.Peer-Reviewed Original ResearchConceptsCerebral cortexLayer ILayer I cellsLayer I neuronsPrimate cerebral cortexCajal-Retzius cellsSubpial granular layerGABAergic neuronsGABAergic interneuronsCortical plateI neuronsGanglionic eminenceMacaque monkeysPial surfaceOlfactory primordiumI cellsNeuronsMonth periodLong gestationGranular layerCortexUltrastructural analysisCorticogenesisCellsPrimates
1998
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processes
1995
Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations
Komuro H, Rakic P. Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations. Journal Of Neuroscience 1995, 15: 1110-1120. PMID: 7869087, PMCID: PMC6577849, DOI: 10.1523/jneurosci.15-02-01110.1995.Peer-Reviewed Original ResearchConceptsCell movementCell migrationPlasma membraneShort stationary phaseCerebellar slice preparationGranule cell migrationMolecular mechanismsMembrane flowConfocal microscopic studiesIndividual cellsNeuronal migrationConfocal microscopyCytological aspectsDil crystalsCellsMembraneBergmann glial fibersGranule cellsMigrationMicrons/hrOld micePostnatal lifeConsiderable variationAcute cerebellar slice preparationStationary phase
1994
Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey
Lidow, Rakic P. Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey. Journal Of Neuroscience 1994, 14: 4064-4078. PMID: 8027763, PMCID: PMC6577033, DOI: 10.1523/jneurosci.14-07-04064.1994.Peer-Reviewed Original ResearchConceptsTransient embryonic zonesBeta-adrenergic receptorsCortical plateAdrenergic receptor subtypesSubplate zoneReceptor subtypesCerebral wallRhesus monkeysAlpha 1Alpha 1 sitesAlpha 2Alpha 2 receptorsAlpha 1 receptorsEmbryonic zonesIntensive proliferative activityReceptor autoradiographyCortical neuronsSubventricular zoneCortical developmentOccipital lobeBeta receptorsAdrenergic receptorsAdrenergic sitesVisual cortexGerminal zoneIdentification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells
Cameron R, Rakic P. Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. Journal Of Neuroscience 1994, 14: 3139-3155. PMID: 8182462, PMCID: PMC6577439, DOI: 10.1523/jneurosci.14-05-03139.1994.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsMembrane proteinsCell-cell recognitionFocal adhesion plaquesApparent molecular massRadial glial cell processesNeuronal cell migrationCerebellar glial cellsActin cytoskeletonGlial cell processesMicrotubule cytoskeletonNon-neural tissuesSurface microdomainsMembrane polypeptidesIndividual proteinsAdhesion plaquesProcess-bearing astrocytesIntact microtubulesAdult stageMolecular massCell migrationMigration eventsIntegrin subunitsJunctional complexesSynaptogenesis in the Prefrontal Cortex of Rhesus Monkeys
Bourgeois J, Goldman-Rakic P, Rakic P. Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys. Cerebral Cortex 1994, 4: 78-96. PMID: 8180493, DOI: 10.1093/cercor/4.1.78.Peer-Reviewed Original ResearchConceptsYears of ageSynaptic densityPrefrontal cortexCortical plateMotor areaRhesus monkeysDensity of synapsesQuantitative electron microscopic analysisCourse of synaptogenesisHigh synaptic densityWhole cortical thicknessPrefrontal association areasMacaque prefrontal cortexCerebral cortexDendritic shaftsSupragranular layersCortical circuitryCortical thicknessCortical mantleAssociation areasSynapse formationDay 47Selective increaseCortexSynapses
1993
Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage
Bourgeois J, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. Journal Of Neuroscience 1993, 13: 2801-2820. PMID: 8331373, PMCID: PMC6576672, DOI: 10.1523/jneurosci.13-07-02801.1993.Peer-Reviewed Original ResearchConceptsPrimary visual cortexSynaptic contactsVisual cortexCortical plateSynaptic densityDendritic spinesPostnatal yearDensity of synapsesThird postnatal monthFirst postnatal yearTime of pubertyMicrons 3Asymmetric synapsesDendritic shaftsLayer VICalcarine fissureCortical neuronsLayer IVPostnatal monthLaminar positionMacaque monkeysFunctional maturationRhesus monkeysAdult levelsNeuropil
1992
Scheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development
Lidow M, Rakic P. Scheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development. Cerebral Cortex 1992, 2: 401-416. PMID: 1330122, DOI: 10.1093/cercor/2.5.401.Peer-Reviewed Original ResearchConceptsMonoaminergic receptorsCortical layersReceptor densityCytoarchitectonic areasPostnatal developmentNeurotransmitter receptor expressionSuperficial cortical layersMonths of ageTime of pubertyCerebral cortexCortical maturationPostnatal monthReceptor expressionPrimary motorPrimate neocortexVisual cortexRhesus monkeysFourth monthReceptorsMonthsReceptor sitesCortexDevelopmental changesDevelopmental courseTransient overproduction
1991
A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey
Eckenhoff M, Rakic P. A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey. Brain Research 1991, 64: 129-135. PMID: 1786637, DOI: 10.1016/0165-3806(91)90216-6.Peer-Reviewed Original ResearchSynchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.
Lidow M, Goldman-Rakic P, Rakic P. Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10218-10221. PMID: 1658799, PMCID: PMC52899, DOI: 10.1073/pnas.88.22.10218.Peer-Reviewed Original ResearchSynaptogenesis in Monkey Somatosensory Cortex
Zecevic N, Rakic P. Synaptogenesis in Monkey Somatosensory Cortex. Cerebral Cortex 1991, 1: 510-523. PMID: 1822755, DOI: 10.1093/cercor/1.6.510.Peer-Reviewed Original ResearchConceptsYears of ageSomatosensory cortexSynaptic densityPostcentral gyrusLate fetal ageUpper limb representationDensity of synapsesMonkey somatosensory cortexNumber of synapsesSecond postnatal monthRate of synaptogenesisMicrons 3Timing of synaptogenesisPost-natal lifeSymmetrical synapsesDendritic shaftsSynaptic eliminationSomatosensory functionPostnatal monthDendritic spinesNeocortical areasCortical growthEarly infancyNeurotransmitter receptorsLimb representationCytogenesis in the monkey retina
la Vail M, Rapaport D, Rakic P. Cytogenesis in the monkey retina. The Journal Of Comparative Neurology 1991, 309: 86-114. PMID: 1894769, DOI: 10.1002/cne.903090107.Peer-Reviewed Original Research
1990
Hypercolumns in primate visual cortex can develop in the absence of cues from photoreceptors.
Kuljis R, Rakic P. Hypercolumns in primate visual cortex can develop in the absence of cues from photoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 5303-5306. PMID: 2164675, PMCID: PMC54311, DOI: 10.1073/pnas.87.14.5303.Peer-Reviewed Original ResearchConceptsLayers II/IIINeuropeptide YInterblob regionsVisual cortexAspiny stellate cellsCytochrome oxidase-rich blobsCytochrome oxidase blobsPrimate visual cortexRetinal ablationCerebral cortexRetinal neuronsDistinct physiological propertiesControl animalsStellate cellsOperated animalsMacaque monkeysSynaptic connectionsCortexPattern visionRetinal photoreceptorsNeuronsChemoarchitectonic organizationAbsence of cuesColor visionPhotoreceptorsAxon overproduction and elimination in the corpus callosum of the developing rhesus monkey
LaMantia A, Rakic P. Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey. Journal Of Neuroscience 1990, 10: 2156-2175. PMID: 2376772, PMCID: PMC6570389, DOI: 10.1523/jneurosci.10-07-02156.1990.Peer-Reviewed Original ResearchConceptsCallosal axonsAxon eliminationNewborn monkeysCorpus callosumRhesus monkeysCallosal projection zonePrimate cerebral cortexInterhemispheric projectionsCallosal projectionsCerebral cortexSynaptic densityPostnatal monthPostnatal weekSupernumerary axonsPostnatal eliminationMonkey cortexProjection zonesFetal developmentAdult valuesAxonsLocal proliferationCallosumDay 65BirthMonkeys
1989
Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life
Zecevic N, Bourgeois J, Rakic P. Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life. Brain Research 1989, 50: 11-32. PMID: 2582602, DOI: 10.1016/0165-3806(89)90124-7.Peer-Reviewed Original ResearchConceptsMotor cortexSynaptic densityCortical plateRhesus monkeysDensity of synapsesTransient subplate zonePrimate motor cortexSecond postnatal monthTime of birthVolume of neuropilMicrons 3Non-human primatesSubplate zoneSymmetric synapsesAsymmetric synapsesDendritic shaftsSynaptic contactsLaminar distributionFirst synapsePostnatal monthDendritic spinesPostnatal lifeSynaptic connectionsAdult levelsCortexSynaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction.
Bourgeois J, Jastreboff P, Rakic P. Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4297-4301. PMID: 2726773, PMCID: PMC287439, DOI: 10.1073/pnas.86.11.4297.Peer-Reviewed Original ResearchConceptsVisual cortexSynaptic overproductionVisual stimulationFirst postnatal monthTime of deliveryAge-matched controlsPrimary visual cortexTime of conceptionControl infantsLaminar distributionPostnatal monthRhesus monkeysCortexQuantitative electron microscopyVisual experienceTime courseSynapsesStimulationMonkeysIntrinsic regulationOverproductionPretermInfantsFetusesWeeks
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic protein
1985
DNA Synthesis and Cell Division in the Adult Primate Braina
RAKIC P. DNA Synthesis and Cell Division in the Adult Primate Braina. Annals Of The New York Academy Of Sciences 1985, 457: 193-211. PMID: 3913364, DOI: 10.1111/j.1749-6632.1985.tb20806.x.Peer-Reviewed Original ResearchConceptsPostembryonic neurogenesisNonmammalian vertebratesCell divisionDNA precursorsPrimate central nervous systemStable populationDNA synthesisNonprimate mammalsCentral nervous systemMature primatesNeuronal additionGlial cellsNervous systemAdult monkeysRetention of memoryAutoradiographic analysisMultiple injectionsVertebratesDevelopmental periodMammalsVariable degreesNeuronsJuvenilesNeurogenesisTurnover
1984
Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey
Eckenhoff M, Rakic P. Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey. The Journal Of Comparative Neurology 1984, 223: 1-21. PMID: 6707248, DOI: 10.1002/cne.902230102.Peer-Reviewed Original Research