2018
Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins
Panda S, Setia M, Kaur N, Shepal V, Arora V, Singh D, Mondal A, Teli A, Tathode M, Gajula R, Padhy L, Shiras A. Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins. PLOS Biology 2018, 16: e2004204. PMID: 30296263, PMCID: PMC6193740, DOI: 10.1371/journal.pbio.2004204.Peer-Reviewed Original ResearchConceptsGenomic stabilityNoncoding RNAsMouse cellsBreast cancer type 1 susceptibility proteinLong intergenic noncoding RNAsIntergenic noncoding RNAsGrowth regulatory signalsLong noncoding RNAHitherto unknown mechanismEukaryotic transcriptomesMitotic regulationCellular homeostasisTranscript pairsCentrosomal proteinsRNA functionMitotic fidelityAntisense transcriptsSusceptibility proteinProtein interactionsEmbryonic developmentFunctional characterisationIndividual transcriptsBRCA1 proteinRegulatory signalsAdult tissues
2013
MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells
Rani S, Rathod S, Karthik S, Kaur N, Muzumdar D, Shiras A. MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro-Oncology 2013, 15: 1302-1316. PMID: 23814265, PMCID: PMC3779040, DOI: 10.1093/neuonc/not090.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternBrain NeoplasmsCalmodulin-Binding ProteinsCell AdhesionCell CycleCell MovementCell ProliferationGliomaHumansMiceMice, Inbred NODMice, SCIDMicroRNAsNeoplastic Stem CellsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSOX9 Transcription FactorConceptsAdducin 3MiR-145Overexpression of moleculesCell proliferationGlioma cellsHNGC-2 cellsModel cell systemMiR-145 promoterTumor suppressive functionMiR-145 functionsGuanine (CpG) islandsMiR-145 overexpressionEctopic expressionGrowth-suppressive effectsMiR-145 lossHuman glioma cellsCell adhesionC-MycFunctional studiesN-cadherinGlioma cell linesGlioblastoma cellsN-mycSOX9E-cadherinWnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma
Kaur N, Chettiar S, Rathod S, Rath P, Muzumdar D, Shaikh M, Shiras A. Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma. Molecular And Cellular Neuroscience 2013, 54: 44-57. PMID: 23337036, DOI: 10.1016/j.mcn.2013.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationCell Transformation, NeoplasticDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsTranscription, GeneticWnt Signaling PathwayWnt1 ProteinWnt3A ProteinConceptsWnt/β-cateninDevelopmental signaling pathwaysTumor progressionΒ-cateninCancer stem cell hypothesisRole of Wnt3aStem cell hypothesisIntra-cranial tumoursStem-like cellsNovel therapeutic strategiesGlioma stemPromotes Tumor ProgressionSignaling pathwaysCell migrationDistinct populationsCell hypothesisGlioma tumorigenesisCell proliferationWnt3aTherapeutic strategiesMalignant transformationTumor developmentPathwayWntGlioma cells
2010
Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells
Reddy E, Chettiar S, Kaur N, Ganeshkumar R, Shepal V, Shanbhag N, Shiras A. Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells. Cancer Gene Therapy 2010, 18: 206-218. PMID: 21109781, DOI: 10.1038/cgt.2010.71.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell ProliferationCyclin-Dependent Kinase Inhibitor p21Down-RegulationFemaleGene Expression Regulation, NeoplasticGliomaHumansMatrix Metalloproteinase 2Melanoma-Specific AntigensMiceMice, SCIDNeoplastic Stem CellsNerve Tissue ProteinsOncogene ProteinsSignal TransductionXenograft Model Antitumor AssaysConceptsGlioma stem cellsStem cellsBrain tumor stem cellsCancer-initiating stem cellsHigh-grade gliomasEffective therapeutic targetingAnti-proliferative effectsGlioma cell invasionMelanoma antigen gene (MAGE) familyCancer stem cell hypothesisInhibits cell proliferationTumor stem cellsCell cycle arrest proteinsInducers of differentiationMMP-9Brain tumorsStem cell hypothesisMMP-2Therapeutic targetingAnti-proliferative functionDlxin-1MAGE familyHNGC-2 cellsCell invasionCell proliferation