MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
Roden C, Lu J. MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis. Current Stem Cell Reports 2016, 2: 183-196. PMID: 27547713, PMCID: PMC4988405, DOI: 10.1007/s40778-016-0057-1.Peer-Reviewed Original ResearchHematopoietic stem cellsStem cellsPost-transcriptional gene regulation mechanismSpecific gene expression programsPost-transcriptional gene expressionSmall non-coding RNAsGene expression programsLeukemia stem cellsGene regulation mechanismsFunction of miRNAsNon-coding RNAsStudy of miRNAsRole of miRNAsCell signaling pathwaysLSC biologyCancer stem cell conceptStem cell fieldEpigenetic machineryExpression programsHSC emergenceEpigenetic programsStem cell conceptEpigenetic regulatorsDifferentiated progenyHSC nicheRegulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family
Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports 2016, 7: 43-54. PMID: 27373925, PMCID: PMC4945581, DOI: 10.1016/j.stemcr.2016.05.014.Peer-Reviewed Original ResearchConceptsDNA methylation stateEmbryonic stem cellsInduced pluripotent stem cellsHuman somatic cell reprogrammingSomatic cell reprogrammingMethylation stateCell reprogrammingMiR-29 familyDNA methylation landscapeImportant epigenetic regulatorsStem cellsOverexpression of Oct4Global DNA methylationMiRNA-based approachesPluripotent stem cellsMethylation landscapeHistone modificationsDNA demethylationEpigenomic changesEarly reprogrammingEpigenetic regulatorsEpigenetic differencesDNA methylationHydroxymethylation analysisReprogramming