AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization
Khurana S, Coyle E, Manischewitz J, King L, Gao J, Germain R, Schwartzberg P, Tsang J, Golding H. AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization. Npj Vaccines 2018, 3: 40. PMID: 30302282, PMCID: PMC6167326, DOI: 10.1038/s41541-018-0076-2.Peer-Reviewed Original ResearchAntibody responseWhole genome-fragment phage display librariesGenome-fragment phage display librariesNeuraminidase inhibition antibody titersVaccine-induced antibody responsesFragment phage display librariesHeterologous H5N1 strainsPolyclonal antibody responsePandemic influenza strainsAffinity maturationNAI titerUnadjuvanted vaccineAntibody titersNeutralization titersSeasonal strainsVaccine platformImmune responseInfluenza strainsAS03Antibody affinity maturationFuture vaccinesImmune memoryViral hemagglutininEpitope diversityVaccine