Featured Publications
Patient‐detectable responsive neurostimulation as a seizure warning system
Quraishi IH, Hirsch LJ. Patient‐detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemFocal impaired awareness seizuresProportion of patientsQuality of lifeSeizure warningTolerable symptomsClinical seizuresLatter therapySelect patientsAwareness seizuresEpileptiform activityEarly recognitionResponsive neurostimulationEpileptiform patternsCognitive impairmentPatientsNeurostimulation systemSymptomsSeizuresTherapyTreatment of clustersStimulationSeizure warning systemSeizure recognitionEpilepsyEarly detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugs
Quraishi IH, Mercier MR, Skarpaas TL, Hirsch LJ. Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugs. Epilepsia 2019, 61: 138-148. PMID: 31849045, PMCID: PMC7003822, DOI: 10.1111/epi.16412.Peer-Reviewed Original ResearchConceptsPositive predictive valueEpisode startsLonger episodesSystem patientsPredictive valueFirst weekLong-term treatment trialsBrain-responsive neurostimulationSingle epilepsy centerSingle-center cohortRefractory focal epilepsyGreater reductionMedication adjustmentsClinical improvementClinical responseSeizure frequencyAntiseizure drugsCenter cohortMulticenter cohortEpilepsy centersMedication trialsEffective medicationsEfficacy measuresTreatment trialsFocal epilepsyAn Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents
Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. Journal Of Neuroscience 2019, 39: 7438-7449. PMID: 31350261, PMCID: PMC6759030, DOI: 10.1523/jneurosci.1628-18.2019.Peer-Reviewed Original ResearchConceptsSevere epileptic encephalopathyAction potentialsEpileptic encephalopathyFiring rateCurrent-clamp recordingsSodium-activated potassium channelsMaximal firing rateIntensity of firingMean firing rateKCNT1 mutationsCortical neuronsCell-autonomous mechanismsEffective treatmentHuman neuronsPotassium currentActive neuronsNeuronsPotassium channelsCompensatory changesDisease-causing mutationsHyperexcitabilityHuman iPSCEncephalopathyExcitabilityStem cellsDecoding Features of Real-world Navigation from the Human Hippocampus
Graves K, Letrou A, Gray T, Quraishi I, Turk-Browne N. Decoding Features of Real-world Navigation from the Human Hippocampus. Journal Of Vision 2023, 23: 4753. DOI: 10.1167/jov.23.9.4753.Peer-Reviewed Original ResearchGerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original Research
2024
Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment
Sun F, Wang H, Wu J, Quraishi I, Zhang Y, Pedram M, Gao B, Jonas E, Nguyen V, Wu S, Mabrouk O, Jafar-nejad P, Kaczmarek L. Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment. Biomolecules 2024, 14: 1397. DOI: 10.3390/biom14111397.Peer-Reviewed Original ResearchWild-type miceKO miceSpectrum of epilepsy syndromesAntisense oligonucleotidesGain-of-function variantsAntisense oligonucleotide treatmentEpileptic phenotypePotassium channelsKCNT1Molecular profilingOligonucleotide treatmentAnimal modelsEpilepsy syndromesC-terminal mutationsIncreased expressionCerebral cortexMiceExpression of multiple proteinsComprehensive proteomic analysisDisease modelsCortical mitochondriaMolecular differencesDensity of mitochondrial cristaeMitochondrial membraneTreatmentCombined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisNon-lesional Bilateral Mesial Temporal Lobe Epilpesy
Quraishi I, Herlopian A. Non-lesional Bilateral Mesial Temporal Lobe Epilpesy. 2024, 781-818. DOI: 10.1007/978-3-031-23828-4_32.ChaptersMultifocal Epilepsy and Non-dominant Cingulate Lesion
Herlopian A, Gray T, Quraishi I. Multifocal Epilepsy and Non-dominant Cingulate Lesion. 2024, 393-429. DOI: 10.1007/978-3-031-23828-4_18.ChaptersMultifocal epilepsyEEG findings of patientsFindings of patientsAnti-seizure medicationsPrognostic roleSurgical outcomesEEG findingsEEG changesCingulate epilepsyHabitual seizuresIctal tachycardiaAnterior cingulate gyrusEpilepsy monitoring unitVascular lesionsIctal speechPredictive valueOutcome determinantsPatientsMonitor unitsCingulate cortexEpilepsyCingulate gyrusCingulateCortexEEGSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsDisease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
Wu J, Quraishi I, Zhang Y, Bromwich M, Kaczmarek L. Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons. Cell Reports 2024, 43: 113904. PMID: 38457342, PMCID: PMC11013952, DOI: 10.1016/j.celrep.2024.113904.Peer-Reviewed Original ResearchInhibitory neuronsRegulation of neuronal excitabilityPotassium channel mutationsVoltage-dependent sodiumInhibitory cortical neuronsGain-of-function mutationsAxon initial segmentKCNT1 geneNeuronal excitabilityChannel subunitsChannel mutationsNetwork hyperexcitabilityMouse modelNeuron typesCortical neuronsTreat epilepsyNeuronsExcitable neuronsNeurological disordersSevere intellectual disabilityMutationsInitial segmentKCNT1ExpressionHyperexcitabilitySlack (KCNT1) potassium channels regulate levels of proteins of the inner mitochondrial membrane
Wang H, Wu J, Sun F, Wu S, Jafar-nejad P, Quraishi I, Pedram M, Kaczmarek L. Slack (KCNT1) potassium channels regulate levels of proteins of the inner mitochondrial membrane. Biophysical Journal 2024, 123: 250a. DOI: 10.1016/j.bpj.2023.11.1582.Peer-Reviewed Original Research
2023
Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis
Gardin T, Yang A, Moeller J, Quraishi I. Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis. BMJ Case Reports 2023, 16: e254727. PMID: 38035681, PMCID: PMC10689362, DOI: 10.1136/bcr-2023-254727.Peer-Reviewed Case Reports and Technical NotesConceptsAutoimmune atrophic gastritisNitrous oxide useAtrophic gastritisCombined degenerationSpinal cordRecreational nitrous oxide useSubacute combined degenerationVitamin B12 deficiencySubstance use disordersConcomitant etiologiesNeuropsychiatric manifestationsB12 deficiencyNeuropsychiatric sequelaePsychiatric comorbiditySecondary causesClinical pearlsDifferential diagnosisTimely treatmentUse disordersCommon drugsNutritional deficienciesVitamin B12Myelin sheathAlternative causesYoung adultsA multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Fields M, Eka O, Schreckinger C, Dugan P, Asaad W, Blum A, Bullinger K, Willie J, Burdette D, Anderson C, Quraishi I, Gerrard J, Singh A, Lee K, Yoo J, Ghatan S, Panov F, Marcuse L. A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation. Frontiers In Neurology 2023, 14: 1202631. PMID: 37745648, PMCID: PMC10516547, DOI: 10.3389/fneur.2023.1202631.Peer-Reviewed Original ResearchAnterior thalamic nucleiSerious adverse eventsGlobal Clinical Impression ScaleVagal nerve stimulationDrug-resistant epilepsyDeep brain stimulationAdverse eventsMost patientsResponsive neurostimulationSeizure reductionResective surgeryResistant epilepsyImpression ScaleSide effectsMedian baseline seizure frequencyDrug-resistant epilepsy patientsRare serious adverse eventsAnti-seizure medicationsDifferent epilepsy centersMeaningful seizure reductionMedian seizure reductionMedication regimen changesBaseline seizure frequencyMulticenter retrospective studyRetrospective multicenter studyIs MORE better? Accumulating Evidence for ANT DBS in Epilepsy
Quraishi I. Is MORE better? Accumulating Evidence for ANT DBS in Epilepsy. Epilepsy Currents 2023, 23: 357-359. PMID: 38269353, PMCID: PMC10805093, DOI: 10.1177/15357597231197086.Commentaries, Editorials and LettersIntracranial Entrainment Reveals Statistical Learning across Levels of Abstraction
Sherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 35: 1312-1328. PMID: 37262357, DOI: 10.1162/jocn_a_02012.Peer-Reviewed Original ResearchIctal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008)
Saab L, Jiang J, Quraishi I, Herlopian A. Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204225.Peer-Reviewed Original ResearchNonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials
Govindaraju A, Quraishi I, Lysakowski A, Eatock R, Raphael R. Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2207466120. PMID: 36595693, PMCID: PMC9926171, DOI: 10.1073/pnas.2207466120.Peer-Reviewed Original ResearchConceptsNonquantal transmissionAfferent neuronsHair cellsPresynaptic hair cellsPrimary afferent neuronsAction potential latencyVestibular hair cellsCalyx afferentsPotential latencySynaptic terminalsVestibular signalsSynaptic cleftNeural circuitsHead positionPossible roleGap junctionsNeuronsSynapsesSynapseCleftCellsCalyxAfferents
2022
Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.Peer-Reviewed Original ResearchConceptsVisual cortexStatistical learningIntracranial recordingsStatistical learning taskBehavioural Memory TestMultivariate pattern analysisLong-term memoryExpense of memoryEncoding of informationHuman visual cortexStorage of experienceNew experiencesEpisodic memoryMemory researchMemory testFrequency taggingRapid streamGuide behaviorLearning taskNew predictive relationshipNeural predictionHuman intracranial EEGWeak expectationsNeural activityMemory formationElectronic seizure diaries for clinical care and research
Gray TE, Hirsch LJ, Quraishi IH. Electronic seizure diaries for clinical care and research. Epileptic Disorders 2022, 24: 803-811. PMID: 35811431, DOI: 10.1684/epd.2022.1451.Peer-Reviewed Original Research