2024
Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease
Li Y, Sun R, Lai C, Liu K, Yang H, Peng Z, Xu D, Huang F, Tang K, Peng Y, Liu X. Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease. Journal Of Translational Medicine 2024, 22: 518. PMID: 38816750, PMCID: PMC11137967, DOI: 10.1186/s12967-024-05317-1.Peer-Reviewed Original ResearchConceptsGut microbiotaFecal microbiota transplantationHyperbaric oxygen therapyDysbiosis of gut microbiotaComposition of gut microbiotaC-reactive proteinCrohn's Disease Activity IndexRegulating gut microbiotaHost physiological conditionAbundance of EscherichiaDisease activity indexCrohn's diseaseClostridium XIVaModulating dysbiosisGene sequencesSystematic inflammationMicrobial diversityOxygen therapyPatients treated with hyperbaric oxygen therapyMicrobiotaColitis mouse modelLevels of C-reactive proteinMicrobiota transplantationSerum C-reactive proteinEffect of hyperbaric oxygen therapyMetagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice
Chen H, Huang S, Zhao Y, Sun R, Wang J, Yao S, Huang J, Yu Z. Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice. Microbiology Spectrum 2024, 12: e03735-23. PMID: 38441977, PMCID: PMC10986500, DOI: 10.1128/spectrum.03735-23.Peer-Reviewed Original ResearchConceptsTaxonomic compositionGut microbiomeIntestinal microbiomeFunctional genesKEGG OrthologyMetagenomic analysisIntestinal microbiotaRegulatory mechanismsFunction of gut microbiomeComposition of gut microbiotaAbundance of functional genesMetagenomic sequencingGene functionGut microbiotaPotential regulatory mechanismSpecies levelIntervention of probioticsBacillus amyloliquefaciensMicrobiomeGenesMicrobiotaHost immune responseProbiotic interventionMetabolic reactionsSchistosoma japonicum</i>
2023
Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health
Yao S, Zhao Y, Chen H, Sun R, Chen L, Huang J, Yu Z, Chen S. Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health. Nutrients 2023, 15: 3460. PMID: 37571397, PMCID: PMC10420685, DOI: 10.3390/nu15153460.Peer-Reviewed Original ResearchConceptsGut microbiotaGut healthComposition of gut microbiotaGut microbiota of miceProtecting gut healthRRNA gene sequencesMicrobiota of miceGut microbiota changesGene sequencesAlpha diversityHigh fiber dietMicrobiota changesPathogenic bacteriaMicrobiotaGutGenusHigh-protein dietSwitching dietsDietary impactExperimental timeframeBacteriaProbioticsHigh-protein diet groupSequenceAIN-93G dietBacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome
Chen H, Sun R, Wang J, Yao S, Batool S, Yu Z, Huang S, Huang J. Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome. Frontiers In Cellular And Infection Microbiology 2023, 13: 1172298. PMID: 37265494, PMCID: PMC10230073, DOI: 10.3389/fcimb.2023.1172298.Peer-Reviewed Original ResearchConceptsIntestinal microbiomeAbundances of potential pathogenic bacteriaRecovery of diversityRRNA gene sequencesPotential pathogenic bacteriaPathological organ damageEscherichia-ShigellaGene sequencesInteraction networkMammalian hostsBacillus amyloliquefaciensPathogenic bacteriaMicrobiomeIntestinal microenvironmentEffective therapeutic agentSchistosoma japonicumEcological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice
Sun R, Chen H, Yao S, Yu Z, Lai C, Huang J. Ecological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice. Frontiers In Cellular And Infection Microbiology 2023, 13: 1178714. PMID: 37153156, PMCID: PMC10157258, DOI: 10.3389/fcimb.2023.1178714.Peer-Reviewed Original Research
2022
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer
Li Y, Gan Y, Liu J, Li J, Zhou Z, Tian R, Sun R, Liu J, Xiao Q, Li Y, Lu P, Peng Y, Peng Y, Shu G, Yin G. Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. Signal Transduction And Targeted Therapy 2022, 7: 87. PMID: 35351858, PMCID: PMC8964798, DOI: 10.1038/s41392-022-00902-6.Peer-Reviewed Original ResearchConceptsOxaliplatin resistanceColorectal cancerTumor growthMEIS1 expressionCell sensitivity to oxaliplatinPreventing DNA damage repairCombination of oxaliplatinSurvival of CRC patientsTreatment of colorectal cancerSensitivity to oxaliplatinEZH2 inhibitor GSK126Suppressed tumor growthReverse oxaliplatin resistanceFrontline treatmentAcquired resistanceCRC patientsInhibitor GSK126OxaliplatinFEN1 expressionTherapeutic strategiesDNA damage repairELFN1-AS1Cell survivalMeis1Patients